Plasma coenzyme Q10 reference intervals, but not redox status, are affected by gender and race in self-reported healthy adults
Plasma coenzyme Q10 reference intervals, but not redox status, are affected by gender and race in self-reported healthy adults
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DOI：
10.1016/s0009-8981(03)00137-2
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发表时间：
2003-06-01
影响因子：
5
通讯作者：
Pesce, AJ
中科院分区：
文献类型：
--
作者：
Miles, MV;Horn, PS;Pesce, AJ
背景：据报道，许多患者群体的辅酶 Q(10) 浓度异常，包括某些心血管、神经、血液、肿瘤、肾脏和代谢疾病。然而，这些研究中的对照通常数量有限、筛选不善且统计评估不充分。本研究的目的是确定自我报告的健康成人血浆中泛醌-10、泛醇-10 和总辅酶 Q(10) 浓度的参考区间。方法：普林斯顿患病率随访研究的参与者（n = 148）通过问卷调查被确定为健康。测量血浆中的脂质谱、泛醌-10、泛醇-10 和总辅酶 Q(10) 浓度。用于确定参考区间的方法是结合异常值检测和适当分位数的稳健点估计的过程。结果：泛醇-10和总辅酶Q(10)在男性和女性之间存在显着差异。除泛醇-10 总 Q(10) 分数外，在所有情况下，黑人的 Q(10) 测量值均显着高于白人。结论：泛醇-1/总辅酶 Q(10) 的分数是自我报告的健康成年人中严格监管的指标，并且与性别和种族差异无关。某些辅酶 Q(10) 测量值可能需要根据性别和种族特征建立不同的参考区间。 (C) 2003 Elsevier Science B.V. 保留所有权利。
Background: Abnormal concentrations of coenzyme Q(10) have been reported in many patient groups, including certain cardiovascular, neurological, hematological, neoplastic, renal, and metabolic diseases. However, controls in these studies are often limited in number, poorly screened, and inadequately evaluated statistically. The purpose of this study is to determine the reference intervals of plasma concentrations of ubiquinone-10, ubiquinol-10, and total coenzyme Q(10) for self-reported healthy adults. Methods: Adults (n = 148), who were participants in the Princeton Prevalence Follow-up Study, were identified as healthy by questionnaire. Lipid profiles, ubiquinone-10, ubiquinol-10, and total coenzyme Q(10) concentrations were measured in plasma. The method used to determine the reference intervals is a procedure incorporating outlier detection followed by robust point estimates of the appropriate quantiles. Results: Significant differences between males and females were present for ubiquinol-10 and total coenzyme Q(10). Blacks had significantly higher Q(10) measures than whites in all cases except for the ubiquinol-10 total Q(10) fraction. Conclusions: The fraction of ubiquinol-1/total coenzyme Q(10) is a tightly regulated measure in self-reported healthy adults, and is independent of sex and racial differences. Different reference intervals for certain coenzyme Q(10) measures may need to be established based upon sex and racial characteristics. (C) 2003 Elsevier Science B.V. All rights reserved.