Targeted neurorehabilitation strategies in post-stroke aphasia.
Targeted neurorehabilitation strategies in post-stroke aphasia.
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DOI：
10.3233/rnn-231344
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发表时间：
2023
影响因子：
2.8
通讯作者：
Kielar, Aneta
中科院分区：
文献类型：
--
作者：
Shah-Basak, Priyanka;Boukrina, Olga;Li, Xin Ran;Jebahi, Fatima;Kielar, Aneta
失语症是一种使人衰弱的语言障碍，影响着全世界数百万人。大约40%的中风幸存者发展为慢性失语症，导致终身残疾。本文综述了外在和内在的神经调节技术，旨在提高失语症中风幸存者的言语和语言治疗的效果。我们讨论了现有的证据支持使用经颅直流电刺激（tDCS），重复经颅磁刺激，和功能磁共振成像（fMRI）的实时神经反馈失语症康复。本综述系统地评价了专注于治疗后结果优化和转移到功能技能的专门方法的有效性和实施的研究。它考虑刺激目标的确定和各种靶向方法。神经调节干预的临床实践的翻译进行了探讨，强调泛化和功能的沟通。该综述还涵盖了实时功能磁共振成像神经反馈，讨论了目前的疗效和基本的实施参数的证据。最后，我们提出了未来失语症神经调节研究的方向。这篇全面的综述旨在为广大有兴趣将神经调节纳入失语症治疗的研究人员和临床医生提供资源。
Aphasia is a debilitating language impairment, affecting millions of people worldwide. About 40% of stroke survivors develop chronic aphasia, resulting in life-long disability. This review examines extrinsic and intrinsic neuromodulation techniques, aimed at enhancing the effects of speech and language therapies in stroke survivors with aphasia. We discuss the available evidence supporting the use of transcranial direct current stimulation (tDCS), repetitive transcranial magnetic stimulation, and functional MRI (fMRI) real-time neurofeedback in aphasia rehabilitation. This review systematically evaluates studies focusing on efficacy and implementation of specialized methods for post-treatment outcome optimization and transfer to functional skills. It considers stimulation target determination and various targeting approaches. The translation of neuromodulation interventions to clinical practice is explored, emphasizing generalization and functional communication. The review also covers real-time fMRI neurofeedback, discussing current evidence for efficacy and essential implementation parameters. Finally, we address future directions for neuromodulation research in aphasia. This comprehensive review aims to serve as a resource for a broad audience of researchers and clinicians interested in incorporating neuromodulation for advancing aphasia care.