Altered thalamic neurotransmitters metabolism and functional connectivity during the development of chronic constriction injury induced neuropathic pain
Altered thalamic neurotransmitters metabolism and functional connectivity during the development of chronic constriction injury induced neuropathic pain
复制标题
慢性压迫性损伤诱发神经性疼痛过程中丘脑神经递质代谢和功能连接的改变
DOI：
10.1186/s40659-020-00303-5
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发表时间：
2020-01-01
影响因子：
6.7
通讯作者：
Tao, Jing
中科院分区：
文献类型：
--
作者：
Wang, Zhifu;Huang, Sheng;Tao, Jing
目的探讨慢性压迫性损伤（CCI）所致神经病理性痛（neuropathic pain）发生过程中丘脑神经递质的变化及其功能联系。磁共振波谱（MRS）检测丘脑N-乙酰天门冬氨酸（NAA）和谷氨酸（Glu）。采用功能磁共振成像（fMRI）扫描丘脑与其他脑区的功能连接。结果在病理过程中，同侧大鼠的缩爪阈值明显下降。在神经病理性疼痛状态下，丘脑中Glu浓度的增加和NAA水平的降低与机械性异常性疼痛显著相关。神经病理性疼痛过程中丘脑局部均匀性（ReHo）降低。CCI术后不同时间点（7、14、21 d），丘脑与延髓和躯体感觉皮层的功能连接均显著增强。结论CCI术后神经病理性疼痛时，丘脑NAA和Glu水平的动态变化是导致丘脑功能连接过度兴奋的重要原因。丘脑-丘脑功能联系的增强可能对神经病理性疼痛的发生有重要影响。
BackgroundTo investigate the thalamic neurotransmitters and functional connections in the development of chronic constriction injury (CCI)-induced neuropathic pain.MethodsThe paw withdrawal threshold was measured by mechanical stimulation the right hind paw with the von frey hair in the rats of CCI-induced neuropathic pain. The N-acetylaspartate (NAA) and Glutamate (Glu) in thalamus were detected by magnetic resonance spectrum (MRS) process. The thalamic functional connectivity with other brain regions was scanned by functional magnetic resonance image (fMRI).ResultsThe paw withdrawal threshold of the ipsilateral side showed a noticeable decline during the pathological process. Increased concentrations of Glu and decreased levels of NAA in the thalamus were significantly correlated with mechanical allodynia in the neuropathic pain states. The thalamic regional homogeneity (ReHo) decreased during the process of neuropathic pain. The functional connectivity among the thalamus with the insula and somatosensory cortex were significantly increased at different time points (7, 14, 21 days) after CCI surgery.ConclusionOur study suggests that dynamic changes in thalamic NAA and Glu levels contribute to the thalamic functional connection hyper-excitation during CCI-induced neuropathic pain. Enhanced thalamus-insula functional connection might have a significant effect on the occurrence of neuropathic pain.