Folate, methionine, alcohol, and colorectal cancer in a prospective study of women in the United States
Folate, methionine, alcohol, and colorectal cancer in a prospective study of women in the United States
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DOI：
10.1023/a:1016330609603
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发表时间：
2002-08-01
影响因子：
2.3
通讯作者：
Schatzkin, A
中科院分区：
文献类型：
--
作者：
Flood, A;Caprario, L;Schatzkin, A
目的：我们调查了叶酸，蛋氨酸和酒精摄入量的关联，以及这些因素的组合，与结直肠癌（CRC）的风险。方法：我们使用62项食物频率问卷对乳腺癌检测示范项目（BCDDP）随访研究中的45,264名妇女进行饮食评估。经过平均8.5年的随访，490例CRC被identified.Results：膳食叶酸与CRC的风险只有轻微的负相关性（RR = 0.86，95%CI 0.65-1.13，高与低五分位数，p趋势= 0.14），和总叶酸的关联是零。在该队列中，每天饮酒超过两份与CRC仅轻微相关（RR = 1.16，95%CI 0.63-2.14）。高酒精和低总叶酸的组合并不会导致CRC的高风险。蛋氨酸和结直肠癌之间没有关联。结论：这项研究表明，酒精摄入量和CRC之间的关联有限。总叶酸和甲硫氨酸与CRC的非相关性，以及叶酸和酒精联合分析的无效结果，表明酒精对CRC的影响与甲基代谢途径无关。
Objective: We investigated the associations of folate, methionine, and alcohol intake, as well as combinations of these factors, with risk of colorectal cancer (CRC).Methods: We assessed diet using a 62-item food-frequency questionnaire among 45,264 women in the Breast Cancer Detection Demonstration Project (BCDDP) Follow-up Study. After an average of 8.5 years of follow-up, 490 cases of CRC were identified.Results: Dietary folate showed only a slight inverse association with the risk of CRC (RR = 0.86, 95% CI 0.65-1.13 for high vs. low quintile, p for trend = 0.14), and the association for total folate was null. Consuming more than two servings of alcohol per day was only slightly associated with CRC in this cohort (RR = 1.16, 95% CI 0.63-2.14). Combinations of high alcohol and low total folate did not result in a higher risk of CRC. There was no association between methionine and colorectal cancer.Conclusions: This study shows limited association between alcohol intake and CRC. The non-association of total folate and methionine with CRC, and the null results from the combined folate and alcohol analyses, suggest that what effect alcohol may have on CRC is unrelated to the methyl-group metabolism pathway.