LY-1 B-CELLS - FUNCTIONALLY DISTINCT LYMPHOCYTES THAT SECRETE IGM AUTOANTIBODIES
LY-1 B-CELLS - FUNCTIONALLY DISTINCT LYMPHOCYTES THAT SECRETE IGM AUTOANTIBODIES
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DOI：
10.1073/pnas.81.8.2494
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发表时间：
1984-01-01
期刊：
影响因子：
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通讯作者：
HERZENBERG, LA
中科院分区：
文献类型：
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作者：
HAYAKAWA, K;HARDY, RR;HERZENBERG, LA
研究了IgM自身抗体产生的机制。伴随表达IgM、IgD、Ia和Ly-1膜糖蛋白的独特B淋巴细胞亚群（Ly-1 B）在NZB B和NZB相关小鼠中以较高频率存在。这些自身免疫动物中的Ly-1 B亚群负责用培养的NZ B脾细胞证明的自发IgM分泌，并且含有分泌针对单链DNA和胸腺细胞的典型NZ B IgM自身抗体的细胞。正常小鼠品系（和NZ B）中的Ly-1 B群体实际上包含所有分泌与菠萝蛋白酶处理的小鼠红细胞反应的IgM自身抗体的脾细胞。由于不同的B细胞亚群（IgM+、IgD-、Ly-1-）分泌应答外源性抗原而产生的大部分IgM抗体，因此Ly-1 B细胞显然构成在某些类型的自身免疫中重要的功能上不同的B细胞群。
The mechanisms responsible for IgM autoantibody production were studied. A unique subpopulation of B lymphocytes (Ly-1 B) that concomitantly expresses IgM, IgD, Ia and Ly-1 membrane glycoproteins is present at higher frequencies in NZB and NZB-related mice. The Ly-1 B subpopulation in these autoimmune animals is responsible for the spontaneous IgM secretion demonstrated with cultured NZB spleen cells and contains the cells that secrete typical NZB IgM autoantibodies to single-stranded DNA and to thymocytes. The Ly-1 B population in normal mouse strains (and in NZB) contains virtually all of the spleen cells that secrete IgM autoantibodies reactive with bromelain-treated mouse erythrocytes. Since a different B-cell subpopulation (IgM+, IgD-, Ly-1-) secretes most of the IgM antibodies produced in responses to exogenous antigens, Ly-1 B cells apparently constitute a functionally distinct B cell population important in certain kinds of autoimmunity.