Hyperhyaluronanemia in alcoholic hepatitis is associated with increased levels of circulating soluble intercellular adhesion molecule-1.
Hyperhyaluronanemia in alcoholic hepatitis is associated with increased levels of circulating soluble intercellular adhesion molecule-1.
复制标题
DOI：
10.1111/j.1530-0277.1998.tb03915.x
复制
发表时间：
1998-09
期刊：
影响因子：
--
通讯作者：
D. Hill;I. Deaciuc;C. McClain
中科院分区：
文献类型：
--
作者：
D. Hill;I. Deaciuc;C. McClain
本研究旨在探讨肝窦内皮细胞(SEC)在酒精性肝炎临床病程中的作用。研究对象为20例中、重度肝炎患者，平均年龄49.4±11.0岁。根据患者的饮酒史和实验室检查，包括血清转氨酶、胆红素、白细胞总数、中性粒细胞计数和凝血酶原时间。同时检测C反应蛋白和白介素6作为肝脏急性期反应的标志物。在6个月的观察期内，与循环中可溶性细胞间黏附分子(SICAM)-1的水平平行地检测SEC功能状态的标志物--循环透明质酸水平。所有患者都在第一个月住院，并在研究期间被鼓励戒酒。在6个月的观察期内，透明质酸(542+/-32 ng x ml(-1)血清)和sICAM-1(488+/-70 ng x ml(-1)血清)的初始升高水平逐渐下降，最终达到接近健康受试者的水平。SEC功能/激活的这两项指标的变化与胆红素呈正相关。这些数据表明，以血清透明质酸和SICAM-1反映的SEC功能/激活异常在酒精性肝炎中显著，这些变化在停止饮酒后较短的时间内得到改善。
The purpose of this study was to evaluate the role of the sinusoidal endothelial cell (SEC) during the clinical course of alcoholic hepatitis. Twenty consenting patients (mean age: 49.4 +/- 11.0 years) with moderate or severe hepatitis were studied. The patients were selected and characterized according to their history of drinking and laboratory profile, including serum aminotransferases, bilirubin, total white blood cell and neutrophil count, and prothrombin times. C-reactive protein and interleukin-6 were also measured as markers of the hepatic acute phase response. A marker of the SEC functional state, the circulating level of hyaluronan, was measured in parallel with the circulating levels of soluble intercellular adhesion molecule (sICAM)-1 over a 6-month observation period. All patients were hospitalized for the first month and encouraged to abstain from drinking for the duration of the study. The initial increased levels of both hyaluronan (542 +/- 32 ng x ml(-1) serum) and sICAM-1 (488 +/- 70 ng x ml(-1) serum), gradually fell during the 6-month observation period, eventually reaching values close to those seen in healthy subjects. A positive correlation was obtained between changes in these two markers of SEC function/activation on the one hand, and between these two tests and bilirubin, on the other hand. These data indicate that abnormalities of SEC function/activation, as reflected by serum hyaluronan and siCAM-1, are prominent in alcoholic hepatitis, and these alterations improve within relatively short periods of time after cessation of alcohol consumption.