Dietary epidemiology of cancer of the colon in western New York.
Dietary epidemiology of cancer of the colon in western New York.
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纽约州西部结肠癌的饮食流行病学。
DOI：
10.1093/oxfordjournals.aje.a114997
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发表时间：
1988
影响因子：
5
通讯作者：
West,D
中科院分区：
文献类型：
--
作者：
Graham,S;Marshall,J;Haughey,B;Mittelman,A;Swanson,M;Zielezny,M;Byers,T;Wilkinson,G;West,D
作者在纽约县（包括布法罗、尼亚加拉福尔斯和罗切斯特）采访了428例病理证实的结肠癌病例和年龄、性别、种族和社区相匹配的对照组。分别研究发现，男性和女性患结肠癌的风险似乎随着摄入的总脂肪和总卡路里的增加而增加。此外，我们发现风险随着相对体重的克托莱指数（体重（kg）/身高（m2））的增加而增加。膳食纤维与风险仅存在不确定性。在一项回归分析中，脂肪和克托莱指数与风险增加相关，该分析调整了每个因素以及纤维，年龄和社会经济地位。卡路里和克托莱指数也是如此。未来的努力，以澄清可能的保护作用，纤维和解开脂肪和热量的影响需要进行。摄入的卡路里和肥胖都与风险增加有关，这一事实表明研究卡路里消耗的重要性。
The authors interviewed 428 pathologically confirmed cases of colon cancer and controls matched on age, sex, race, and neighborhood in the New York counties containing the cities of Buffalo, Niagara Falls, and Rochester. Risk of colon cancer in both males and females, studied separately, appeared to increase with the amount of total fats and total calories ingested. In addition, we found the risk to increase with increases in the Quetelet index of relative weight (weight (kg)/height (m2)) Dietary fiber was only equivocally associated with risk. Fats and Quetelet index were associated with increased risk in a regression analysis adjusting each factor for the other, as well as for fiber, age, and socioeconomic status. The same was true for calories and Quetelet index. Future efforts to clarify a possible protective role for fiber and to disentangle the effects of fats and calories need to be undertaken. The fact that calories ingested and obesity are each associated with increased risk suggests the importance of studying calorie expenditure.