CHANGES IN MARROW RESERVE OF EOSINOPHILS FOLLOWING RE-EXPOSURE TO FOREIGN PROTEIN
CHANGES IN MARROW RESERVE OF EOSINOPHILS FOLLOWING RE-EXPOSURE TO FOREIGN PROTEIN
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DOI：
10.1111/j.1365-2141.1963.tb05468.x
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发表时间：
1963-01-01
影响因子：
6.5
通讯作者：
HUDSON, G
中科院分区：
文献类型：
--
作者：
HUDSON, G
用定量方法研究致敏豚鼠再次暴露于外源蛋白后，骨髓嗜酸性粒细胞的排出。在一组豚鼠中，在间隔5天的4次外源蛋白皮下注射的最后一次注射后29小时，观察到显著的循环嗜酸性粒细胞增多。与第四次注射用生理盐水代替的组相比，骨髓嗜酸性粒细胞总数明显减少，这几乎完全是成熟和近成熟嗜酸性粒细胞的骨髓“储备”减少的结果。早期形式的数量没有明显变化。似乎在抗原再注射后29小时内，大量带状和分节嗜酸性粒细胞已从骨髓储备中排出到血流中。计算总血液和骨髓群体表明，不到10%的排出的嗜酸性粒细胞仍存在于循环中。研究结果表明，成熟和接近成熟的嗜酸性粒细胞的骨髓储备的重要性，身体的防御机制。它使骨髓能够满足对新的嗜酸性粒细胞的迫切需求，而不会延迟，如果它们的供应依赖于新的生产，这将是不可避免的。偶然观察结果显示嗜碱性粒细胞系列的变化相当相似，但在中性粒细胞系列和任何其他细胞类型中均未观察到变化。
Quantitative methods were used to study the discharge of eosinophils from the bone marrow, following the re-exposure of sensitized guinea-pigs to foreign protein. A striking circulatory eosinophilia was observed in a group of guinea-pigs 29 hours after the last of four subcutaneous injections of foreign protein at 5 day intervals. As compared with a group in which the fourth injection was replaced by saline, the total number of marrow eosinophils showed a marked decrease, which was almost entirely the result of a decrease in the marrow "reserve" of mature and nearly mature eosinophils. No significant change was seen in the numbers of earlier forms. It appears that in the 29 hours following the reinjection of antigen, very large numbers of band and segmented eosinophils had been discharged from the marrow reserve into the blood stream. Calculation of the total blood and bone-marrow populations indicated that less than 10% of the discharged eosinophils were still present in the circulation. The findings indicate the importance of the marrow reserve of mature and nearly mature eosinophils to the defense mechanisms of the body. It enables the bone marrow to meet urgent demands for new eosinophils without the delay which would be inevitable if their supply depended on new production. Incidental observations showed rather similar changes in the basophil series, but no changes were observed in the neutrophil series nor in any other cell type.