Myocardial contractility is early affected in systemic sclerosis: a tissue Doppler echocardiography study.
Myocardial contractility is early affected in systemic sclerosis: a tissue Doppler echocardiography study.
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DOI：
10.1016/j.euje.2004.12.006
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发表时间：
2005-10-01
期刊：
影响因子：
--
通讯作者：
Kahan, Andre
中科院分区：
文献类型：
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作者：
Meune, Christophe;Allanore, Yannick;Kahan, Andre
目的：系统性硬化症(SSC)是一种以频繁心肌受累为特征的结缔组织病。据报道，左心室(LV)功能的改变是罕见的；然而，传统的测量方法可能低估了这种改变。方法和结果：对17例心脏检查、肺动脉压(PAP)和核素左室射血分数(EF)正常的SSc患者进行前瞻性研究。采用单光子发射计算机断层扫描(SPECT)技术检测心肌血流灌注。应用超声心动图(ECHO)、经胸超声心动图(TDE)测量心脏后壁收缩应变率(SR)、舒张期应变率(SR)检测心肌功能，并与15例正常对照组进行比较。所有患者(53+/-8岁；14名女性；收缩压33+/-6毫米汞柱；左心室射血分数67+/-8%)均有心肌SPECT灌注异常。尽管回声正常，但患者的收缩期SR低于对照组(1.7+/-0.5对3.8+/-1.7 cm-1，p
AIMS: Systemic sclerosis (SSc) is a connective tissue disorder characterized by frequent myocardial involvement. Alteration in left ventricular (LV) function is reported to be rare; however, it may be underestimated by conventional measurements. Our aim was to prospectively investigate LV function in SSc patients, using Tissue Doppler echocardiography (TDE), a modern and accurate method of assessing myocardial function.METHODS AND RESULTS: Seventeen consecutive SSc patients with normal cardiac examination, pulmonary artery pressure (PAP) and radionuclide LV ejection fraction (EF) were prospectively investigated. Myocardial perfusion was investigated using single-photon-emission computerized tomography (SPECT). Echocardiography (ECHO), systolic and diastolic strain-rate (SR) measured in the posterior wall by TDE were used to investigate myocardial function, and compared with results of 15 matched controls. All patients (53+/-8 years; 14 women; systolic PAP 33+/-6 mmHg; LVEF 67+/-8%) had myocardial SPECT perfusion abnormalities. Despite normal ECHO, they had lower systolic SR than controls (1.7+/-0.5 versus 3.8+/-1.7 cm-1, p