Plasma potassium concentrations in neonatal diarrhoeic calves are correlated with serum aldosterone concentrations but not with insulin concentrations
Plasma potassium concentrations in neonatal diarrhoeic calves are correlated with serum aldosterone concentrations but not with insulin concentrations
复制标题
DOI：
10.1016/j.tvjl.2017.09.005
复制
发表时间：
2017-12-01
影响因子：
2.2
通讯作者：
Lorenz, Ingrid
中科院分区：
文献类型：
--
作者：
Trefz, Florian M.;Lorenz, Ingrid
高钾血症是新生儿腹泻小牛的一种临床相关电解质失衡，以前与严重脱水和酸血症有关。本研究评估了血浆钾（cK）与血清醛固酮和胰岛素浓度的关系，因为这些激素参与钾稳态的调节。在123例住院的新生儿腹泻小牛中，血清醛固酮（r(s)=0.62）与cK密切相关，但胰岛素浓度（r(s)=0.22）与cK无关。38头高钾血症犊牛（cK > 5.8 mmol/L）血清醛固酮浓度中值分别是85头非高钾血症腹泻犊牛和9头健康对照犊牛的3.2和15.3倍（P < 0.001）。在高钾血症的脱水腹泻小牛中，醛固酮而非胰岛素分泌似乎受到高度刺激，但低血容量和伴随的肾灌注和尿流率的减少可能会限制醛固酮诱导的控制机制在这些动物中的效果。(C) 2017 Elsevier Ltd.版权所有。
Hyperkalaemia is a clinically relevant electrolyte imbalance in neonatal diarrhoeic calves which was previously associated with severe dehydration and acidaemia. The present study assessed the association of plasma potassium (cK) with serum aldosterone and insulin concentrations, since these hormones are involved in the regulation of potassium homeostasis. Serum aldosterone (r(s)=0.62), but not insulin concentrations (r(s)=0.22) were closely correlated to cK in 123 hospitalised neonatal diarrhoeic calves. Median values for serum aldosterone concentrations in 38 hyperkalaemic calves (cK > 5.8 mmol/L) were 3.2 and 15.3 times higher (P < 0.001) than in 85 non-hyperkalaemic diarrhoeic calves and nine healthy control calves, respectively. Aldosterone, but not insulin secretion, appears to be highly stimulated in dehydrated diarrhoeic calves with hyperkalaemia, but hypovolaemia and a concomitant decrease in renal perfusion and urinary flow rate are likely to limit the efficacy of aldosterone-induced control mechanisms in these animals. (C) 2017 Elsevier Ltd. All rights reserved.