Outcomes of pediatric low-grade gliomas treated with radiation therapy: a single-institution study.
Outcomes of pediatric low-grade gliomas treated with radiation therapy: a single-institution study.
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放射治疗儿童低级别胶质瘤的结果：一项单机构研究。
DOI：
10.1097/mph.0000000000000142
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Gauvain,KarenM
中科院分区：
文献类型：
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作者：
Raikar,SunilS;Halloran,DonnaR;Elliot,Michael;McHugh,Michele;Patel,Shaun;Gauvain,KarenM
放射治疗通常被认为是低级别胶质瘤的治疗选择。然而，鉴于放射对发育中的大脑的长期影响，在儿科患者中适当使用放射治疗仍然存在争议。本研究的目的是评估接受放射治疗的儿童低级别胶质瘤患者的无进展生存期（PFS）。数据是通过对1991年至2008年期间在中西部一家三级医疗中心接受治疗的患者进行回顾性图表分析获得的。研究人群包括17例患者，其中8例（47%）在放疗后肿瘤复发。中位随访时间为8.2年，范围为2.3 - 17.2年。诊断时的中位年龄为5.4岁，放射治疗时的中位年龄为9.4岁。3年和10年PFS分别为69%±11.7%和46%± 13.3%。当比较脑干肿瘤与下丘脑/视路肿瘤时，观察到PFS的显著差异（P= 0.019）。基于诊断时年龄、初次手术范围和放射治疗适应症的PFS差异无显著性。需要更大规模的多中心研究来更好地评估这些患者的PFS。
Radiation therapy is often considered the treatment of choice for low-grade gliomas. However, given the long-term effects of radiation on the developing brain, the appropriate use of radiation therapy in pediatric patients remains controversial. The purpose of this study was to evaluate progression-free survival (PFS) of pediatric low-grade glioma patients treated with radiation therapy. Data were obtained through a retrospective chart review of patients treated between 1991 and 2008 from a single tertiary care center in the midwest. The study population consisted of 17 patients, of whom 8 (47%) had tumor recurrence after radiation therapy. The median follow-up time was 8.2 years, with a range of 2.3 to 17.2 years. The median age at diagnosis was 5.4 years, and the median age at radiation therapy was 9.4 years. The 3-and the 10-year PFS were 69%±11.7% and 46%±13.3%, respectively. A significant difference in PFS was seen when comparing brainstem tumors with hypothalamic/optic pathway tumors (P= 0.019). Differences in PFS based on the age at diagnosis, the extent of initial surgery, and indication for radiation therapy were not significant. A larger multicenter study is needed to better assess PFS in these patients.