GROWTH OF HUMAN BASAL-CELL CARCINOMAS TRANSPLANTED TO C57/BALB/C BGJ/BGJ-NU/NU (BEIGE-NUDE) MICE
GROWTH OF HUMAN BASAL-CELL CARCINOMAS TRANSPLANTED TO C57/BALB/C BGJ/BGJ-NU/NU (BEIGE-NUDE) MICE
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DOI：
10.1111/j.1524-4725.1991.tb01316.x
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发表时间：
1991-08-01
期刊：
影响因子：
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通讯作者：
THARP, MD
中科院分区：
文献类型：
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作者：
GRIMWOOD, RE;THARP, MD
本研究的目的是在4个月的观察时间内测量移植基底细胞癌（BCC）到裸小鼠的生长参数。 采用我们报道的皮下移植技术，将人BCC移植到40只雄性Beige裸小鼠体内。 确定每个肿瘤的初始体积和湿重。 每2周用卡尺测量肿瘤，在第120天时确定最终体积，此时收获肿瘤，称重并处理用于常规组织学。 32个肿瘤部位在收获时为持续性肿瘤阳性。 肿瘤体积平均下降51%，平均肿瘤重量下降33%。 基底细胞癌肿瘤小叶周围肥大细胞增多。 结果表明，BCC在裸小鼠体内可存活120天。
The purpose of this study was to measure growth parameters of transplanted basal cell carcinoma (BCC) to beige-nude mice during a 4-month observation time. Forty male beige-nude mice were transplanted with human BCC with our reported subcutaneous implantation technique. Initial volume and wet weight were determined for each tumor. The tumors were measured every 2 weeks by calipers with a final volume determined at 120 days, at which time the tumors were harvested, weighed, and processed for routine histology. Thirty-two tumor sites were positive for persistent tumor at harvest. Tumor volumes declined by an average of 51% and average tumor weight by 33%. There were increased numbers of mast cells surrounding the BCC tumor lobules. These results indicate that BCC can survive for 120 days in the beige-nude mouse.