Hepatic stellate cell: A star cell in the liver
Hepatic stellate cell: A star cell in the liver
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DOI：
10.1016/j.biocel.2009.03.001
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发表时间：
2009-08-01
影响因子：
4
通讯作者：
Perra, Andrea
中科院分区：
文献类型：
--
作者：
Atzori, Luigi;Poli, Giuseppe;Perra, Andrea
肝星状细胞是一种高度通用的细胞类型，在肝脏发育和分化、再生、外源性反应、免疫调节、肝血流控制和炎症反应中发挥重要作用。由于肝星状细胞可以产生和分泌广泛的分子中间体，特别是在疾病状态下持续活化后，肝星状细胞除了在纤维化和细胞外基质重塑中发挥众所周知的关键作用外，肯定参与各种肝脏病理的发病机制。特别是，它们可以积极促进不同病因的肝炎和脂肪性肝炎以及肝癌发生的进展。(C)2009爱思唯尔有限公司保留所有权利。
Hepatic stellate cells represent a highly versatile cytotype that plays a significant role in liver development and differentiation, regeneration, xenobiotic response, immunoregulation, control of hepatic blood flow and inflammatory reactions. Because of the wide panel of molecular intermediates they may produce and secrete, particularly after their sustained activation in a disease state, hepatic stellate cells are definitely involved in the pathogenesis of various liver pathologies, besides the well know key role in fibrosis and extracellular matrix remodelling. In particular, they can actively contribute to the progression of hepatitis and steatohepatitis of different aetiology, and of liver carcinogenesis. (C) 2009 Elsevier Ltd. All rights reserved.