Spectral integration in auditory cortex: Mechanisms and modulation
Spectral integration in auditory cortex: Mechanisms and modulation
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DOI：
10.1016/j.heares.2005.01.014
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发表时间：
2005-08-01
期刊：
影响因子：
2.8
通讯作者：
Rose, HJ
中科院分区：
文献类型：
--
作者：
Metherate, R;Kaur, S;Rose, HJ
听觉皮层参与对频谱时间复杂刺激的处理和感知。然而，实现这一点的机制还不清楚。在这篇综述中，我们研究的证据表明，单皮质神经元接收输入覆盖了大部分的可听频谱。然后，我们提出了一个解剖框架，频谱信息收敛在初级听觉皮层的单个神经元，通过丘脑皮层和皮质内的“水平”通路的组合。就其性质而言，该框架赋予对特定的、频谱时间复杂的刺激的敏感性。最后，为了解决如何频谱整合可以调节，我们展示了如何一个神经调质，乙酰胆碱，可以在假设的框架内，改变在单个神经元的整合。这些研究结果促进了对听觉皮层信息处理的细胞理解。(c)2005 Elsevier B.V.保留所有权利。
Auditory cortex contributes to the processing and perception of spectro temporally complex stimuli. However, the mechanisms by which this is accomplished are not well understood. In this review, we examine evidence that single cortical neurons receive input covering much of the audible spectrum. We then propose an anatomical framework by which spectral information converges on single neurons in primary auditory cortex, via a combination of thalamocortical and intracortical "horizontal" pathways. By its nature, the framework confers sensitivity to specific, spectrotemporally complex stimuli. Finally, to address how spectral integration can be regulated, we show how one neuromodulator, acetylcholine, could act within the hypothesized framework to alter integration in single neurons. The results of these studies promote a cellular understanding of information processing in auditory cortex. (c) 2005 Elsevier B.V. All rights reserved.