Stability and Fragmentation of the Activity Rhythm Across the Sleep-Wake Cycle: The Importance of Age, Lifestyle, and Mental Health
Stability and Fragmentation of the Activity Rhythm Across the Sleep-Wake Cycle: The Importance of Age, Lifestyle, and Mental Health
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DOI：
10.3109/07420528.2013.813528
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发表时间：
2013-01-01
影响因子：
2.8
通讯作者：
Tiemeier, Henning
中科院分区：
文献类型：
--
作者：
Luik, Annemarie I.;Zuurbier, Lisette A.;Tiemeier, Henning
24 小时睡眠-觉醒周期的活动节律部分由生物钟决定，并随着年龄的增长而变化。很少有大规模研究客观地测量一般人群的活动节律。目前以中老年人为基础的研究评估了活动节律如何随年龄变化，并进一步调查了社会人口统计学、心理健康、生活方式和睡眠特征作为活动节律的决定因素。通过体动记录仪客观地测量活动节律。从参与鹿特丹研究的 1734 人（年龄：62 +/- 9.4 岁）收集了至少 96 小时（138 +/- 14 小时，平均值 +/- SD）的记录。通过计算日间稳定性（即节律在几天内的稳定性）和日内变异性（即节律相对于其 24 小时振幅的碎片）来量化活动节律。我们评估了年龄、性别、伴侣存在、就业、认知功能、抑郁症状、体重指数 (BMI)、咖啡使用、饮酒和吸烟作为决定因素。结果表明，年龄较大与更稳定的 24 小时活动概况相关（beta = 0.07，p = 0.02），但也与活动和不活动时段的分布更加分散相关（beta = 0.20，p < 0.001）。抑郁症状较多与节律不稳定（β = -0.07，p = 0.005）和更分散（β = 0.10，p < 0.001）节律相关。高 BMI 和吸烟还与不稳定的节律（BMI：β = -0.11，p < 0.001；吸烟：β = -0.11，p < 0.001）和更分散的节律（BMI：β = 0.09，p < 0.001；吸烟：β = 0.11，p < 0.001）相关。我们得出的结论是，随着年龄的增长，24 小时的活动节律变得更加严格，而长时间保持活动或不活动状态的能力就会受到损害。这两个特征似乎对于老年的主要健康问题都很重要。
The rhythms of activity across the 24-h sleep-wake cycle, determined in part by the circadian clock, change with aging. Few large-scale studies measured the activity rhythm objectively in the general population. The present population-based study in middle-aged and elderly persons evaluated how activity rhythms change with age, and additionally investigated sociodemographics, mental health, lifestyle, and sleep characteristics as determinants of rhythms of activity. Activity rhythms were measured objectively with actigraphy. Recordings of at least 96 h (138 +/- 14 h, mean +/- SD) were collected from 1734 people (age: 62 +/- 9.4 yrs) participating in the Rotterdam Study. Activity rhythms were quantified by calculating interdaily stability, i.e., the stability of the rhythm over days, and intradaily variability, i.e., the fragmentation of the rhythm relative to its 24-h amplitude. We assessed age, gender, presence of a partner, employment, cognitive functioning, depressive symptoms, body mass index (BMI), coffee use, alcohol use, and smoking as determinants. The results indicate that older age is associated with a more stable 24-h activity profile (beta = 0.07, p = 0.02), but also with a more fragmented distribution of periods of activity and inactivity (beta = 0.20, p < 0.001). Having more depressive symptoms was related to less stable (beta = -0.07, p = 0.005) and more fragmented (beta = 0.10, p < 0.001) rhythms. A high BMI and smoking were also associated with less stable rhythms (BMI: beta = -0.11, p < 0.001; smoking: beta = -0.11, p < 0.001) and more fragmented rhythms (BMI: beta = 0.09, p < 0.001; smoking: beta = 0.11, p < 0.001). We conclude that with older age the 24-h activity rhythm becomes more rigid, whereas the ability to maintain either an active or inactive state for a longer period of time is compromised. Both characteristics appear to be important for major health issues in old age.