Magnetically sensitive light-induced reactions in cryptochrome are consistent with its proposed role as a magnetoreceptor
Magnetically sensitive light-induced reactions in cryptochrome are consistent with its proposed role as a magnetoreceptor
复制标题
隐色体的磁敏感光诱导反应与其作为磁感受器的作用相符
DOI：
10.1073/pnas.1118959109
复制
发表时间：
2012-03-27
影响因子：
11.1
通讯作者：
Hore, P. J.
中科院分区：
文献类型：
--
作者：
Maeda, Kiminori;Robinson, Alexander J.;Hore, P. J.
在属于新兴的“量子生物学”领域的生物现象中，有一种观点认为，对磁敏感的化学反应是候鸟的磁罗盘的原因。有人提出，瞬态自由基对形成的光诱导的电子转移反应在隐花色素蛋白质和它们的相干自旋动力学的地磁场的影响，导致的蛋白质的信号状态的量子产率的变化。尽管有各种支持证据，但仍然不清楚隐花色素是否具有响应比热能k（B）T弱几个数量级的磁相互作用所需的性质。在这里，我们证明了动力学和量子产率的光诱导黄素色氨酸自由基对隐花色素确实是磁敏感的。阐明了磁场效应的机制起源，其对测量磁场强度的依赖性，并确定了相关自旋相关，自旋无关和自旋退相干过程的速率。我们认为隐花色素适合作为化学磁感受器。
Among the biological phenomena that fall within the emerging field of "quantum biology" is the suggestion that magnetically sensitive chemical reactions are responsible for the magnetic compass of migratory birds. It has been proposed that transient radical pairs are formed by photo-induced electron transfer reactions in cryptochrome proteins and that their coherent spin dynamics are influenced by the geomagnetic field leading to changes in the quantum yield of the signaling state of the protein. Despite a variety of supporting evidence, it is still not clear whether cryptochromes have the properties required to respond to magnetic interactions orders of magnitude weaker than the thermal energy, k(B)T. Here we demonstrate that the kinetics and quantum yields of photo-induced flavin-tryptophan radical pairs in cryptochrome are indeed magnetically sensitive. The mechanistic origin of the magnetic field effect is clarified, its dependence on the strength of the magnetic field measured, and the rates of relevant spin-dependent, spin-independent, and spin-decoherence processes determined. We argue that cryptochrome is fit for purpose as a chemical magnetoreceptor.