Anti-inflammatory and free radical scavenging activity of Ricinus communis root extract
Anti-inflammatory and free radical scavenging activity of Ricinus communis root extract
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DOI：
10.1016/j.jep.2005.07.029
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发表时间：
2006-02-20
影响因子：
5.4
通讯作者：
Venkataraman, S
中科院分区：
文献类型：
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作者：
Ilavarasan, R;Mallika, M;Venkataraman, S
蓖麻甲醇提取物的抗炎和自由基清除活性。在Wistar白化病大鼠中研究了根。250和500 mg/kg剂量的甲醇提取物p，o。在角叉菜胶诱导的后足肿胀模型中显示出显著（P < 0.001）的抗炎活性。500 mg/kg p.o.剂量的浸提液对棉球肉芽肿模型也有明显的抗炎作用（P < 0.001）。甲醇提取物通过抑制四氯化碳和硫酸亚铁引起的大鼠肝、肾匀浆脂质过氧化反应，表现出明显的自由基清除活性。体外活性测定结果表明，该提取物对DPPH*、一氧化氮和羟自由基的清除活性均有增强作用。研究结果表明蓖麻根甲醇提取物对大鼠急性和慢性炎症模型具有显著的抗炎活性。所观察到的药理活性可能是由于植物提取物中存在的具有各种生物活性的植物化学物质如类黄酮、生物碱和单宁的存在。(c)2005爱思唯尔爱尔兰有限公司保留所有权利。
Anti-inflammatory and free radical scavenging activities of the methanolic extract of Ricinus communis (RCM) (Euphorbiaceae) Linn. root was studied in Wistar albino rats. The methanolic extract at doses 250 and 500 mg/kg p,o. exhibited significant (P < 0.001) anti-inflammatory activity in carrageenan-induced hind paw edema model. The extract at the dose of 500 mg/kg p.o. also exhibited significant (P < 0.001) anti-inflammatory activity in cotton pellet granuloma model. The methanolic extract showed significant free radical scavenging activity by inhibiting lipid peroxidation initiated by carbon tetrachloride and ferrous sulphate in rat liver and kidney homogenates. The extract enhanced free radical scavenging activity of stable radical 2,2-diphenyl-1-picryl-hydrazyl (DPPH*), nitric oxide and hydroxyl radical in in vitro assay methods. The results of the study indicate that the methanolic extract of Ricinus communis root possess significant anti-inflammatory activity in acute and chronic inflammatory models in rats. The observed pharmacological activity may be due to the presence of phytochemicals like flavonoids, alkaloids and tannins present in the plant extract with various biological activites. (c) 2005 Elsevier Ireland Ltd. All rights reserved.