Head Lag in Infants at Risk for Autism: A Preliminary Study
Head Lag in Infants at Risk for Autism: A Preliminary Study
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DOI：
10.5014/ajot.2012.004192
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发表时间：
2012-09-01
影响因子：
2.9
通讯作者：
Bauman, Margaret
中科院分区：
文献类型：
--
作者：
Flanagan, Joanne E.;Landa, Rebecca;Bauman, Margaret
目标。在拉坐过程中，不良的姿势控制是脑瘫和早产人群发育中断的一个预测因素，但尚未在有自闭症风险的婴儿中进行研究。我们研究了6个月大婴儿在拉坐过程中头部滞后与自闭症风险状态之间的关系。高风险参与者是自闭症儿童的兄弟姐妹。我们对40例6-36月龄的高危婴儿进行了前瞻性研究，获得了自闭症或无自闭症的诊断分类。随后，我们对20名高危婴儿和21名低危婴儿进行了组间比较。头滞与36个月大的自闭症谱系障碍显著相关（p= 0.020），在高危婴儿中比在低危婴儿中更常见（p= 0.018）。头部滞后和其他早期发育变化可能与自闭症风险有关，并可能作为神经发育中断的早期指标。结果对职业治疗师在早期干预实践中具有临床意义。
OBJECTIVE. Poor postural control during pull-to-sit is a predictor of developmental disruption in cerebral palsy and preterm populations but has not been examined in infants at risk for autism. We examined the association between head lag during pull-to-sit at age 6 mo and autism risk status.METHOD. High-risk participants were siblings of children with autism. We studied one sample of 40 high-risk infants prospectively from 6-36 mo and obtained diagnostic classifications of autism or no autism. We conducted a subsequent between-group comparison with a new sample of 20 high-risk and 21 low-risk infants.RESULTS. Head lag was significantly associated with autism spectrum disorder at 36 mo (p=.020) and was more frequently observed in high-risk than in low-risk infants (p=.018).CONCLUSION. Head lag with other alterations in early development may be associated with autism risk and may serve as an early indicator of neurodevelopmental disruption. Results have clinical implications for occupational therapists in early intervention practice.