Failure to induce immune tolerance to nitrogen mustard. Intravenous administration preceding topical use in patients with proriasis.
Failure to induce immune tolerance to nitrogen mustard. Intravenous administration preceding topical use in patients with proriasis.
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未能诱导对氮芥的免疫耐受。
DOI：
10.1111/1523-1747.ep13063763
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发表时间：
1972
期刊：
影响因子：
--
通讯作者：
A. Prestia
中科院分区：
文献类型：
--
作者：
R. Baer;P. Michaelides;A. Prestia
氮芥甲氯胺（nh2）是一种强效的接触性过敏原，接触者致敏率高达75%。本文对9例广泛性持续性牛皮癣患者局部应用氢气治疗，试图预防接触致敏，即诱导特异性免疫耐受。在第一次局部应用nh2前14天和7天，分别静脉注射nh2 3mg。4例患者每周重复用nh2局部治疗8 ~ 10周，5例患者每天重复约4周。9例患者中有2例出现接触性nh2过敏。尽管诱导耐受性明显失败，但仍有必要在更大范围的患者中进行进一步的试验，并采用不同的“耐受性”计划和不同的局部治疗计划。
The nitrogen mustard mechlorethamine (NH 2 ) is a potent contact allergen, sensitizing up to 75% of those exposed. An attempt was made to prevent allergic contact sensitization, i.e. to induce specific immunologic tolerance, in 9 patients who were to be treated topically with NH 2 for widespread and persistent psoriasis. Fourteen and 7 days before the first topical application of NH 2 , they were given intravenous injections of 3mg NH 2 . Topical treatment with NH 2 was repeated weekly for 8 to 10 weeks in 4 patients and daily for about 4 weeks in 5 patients. Two of the 9 patients became contact allergic to NH 2 . Despite the apparent failure to induce tolerance, further trials in a larger series of patients and trials with different "tolerogenic" schedules and different topical treatment schedules are warranted.