The mechanism of platelet release.
The mechanism of platelet release.
复制标题
血小板释放机制。
DOI：
10.1182/blood.v56.6.996.bloodjournal566996
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发表时间：
1980
期刊：
影响因子：
20.3
通讯作者：
G. Scurfield
中科院分区：
文献类型：
--
作者：
J. Radley;G. Scurfield
用扫描和透射电子显微镜研究了小鼠骨髓中血小板释放的机制。发现巨核细胞延伸至血窦的胞浆突起发生衰减，在远端，血小板大小的节段之间出现收缩。收缩部位的破裂被认为会释放血小板。微管存在于突起中，沿纵向定向，并集中在狭窄处。观察到的最窄的狭窄直径约为0.2微米，长度为几微米。最窄的狭窄与胞质分裂末期中体和细胞之间的桥梁的结构相似，表明血小板和细胞有共同的释放机制。连续切片显示每个胞质突起均有一个中心粒存在。推测每个细胞质突起中的微管起源于与中心粒有关的组织中心，巨核细胞产生的细胞质突起的数量受其倍性的支配。
The mechanism of platelet release has been studied in mouse bone marrow, using scanning and transmission electron microscopy. Cytoplasmic processes extended into sinusoids by megakaryocytes were found to undergo attenuation, and at the distal end develop constrictions between segments of platelet size. Rupture at sites of constriction is thought to release platelets. Microtubules were present in the processes, orientated longitudinally, and became concentrated in the constrictions. The narrowest constrictions observed were about 0.2 micrometer in diameter and several microns in length. The structural similarity of the narrowest constrictions with those found in bridges separating midbody and cell in the terminal phase of cytokinesis suggests that platelets and cells share a common mechanism for release. The presence of a centriole in each cytoplasmic process was revealed by serial sectioning. It is suggested that the microtubules in each cytoplasmic process originate from an organizing center associated with the centriole, and that the number of cytoplasmic processes that emerge from a megakaryocyte is governed by its ploidy.