A Microfluidic Cytometer for Complete Blood Count With a 3.2-Megapixel, 1.1-μm-Pitch Super-Resolution Image Sensor in 65-nm BSI CMOS
A Microfluidic Cytometer for Complete Blood Count With a 3.2-Megapixel, 1.1-μm-Pitch Super-Resolution Image Sensor in 65-nm BSI CMOS
复制标题
用于全血计数的微流控细胞仪，配备 65 nm BSI CMOS 中的 3.2 兆像素、1.1 μ m 间距超分辨率图像传感器
DOI：
10.1109/tbcas.2017.2697451
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发表时间：
2017-08-01
影响因子：
5.1
通讯作者：
Yu, Hao
中科院分区：
文献类型：
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作者：
Liu, Xu;Huang, Xiwei;Yu, Hao
基于一个320万像素1.1 μ m间距的CMOS图像传感器，采用65 nm的背侧照明工艺，设计了一种无透镜的微流控全血细胞计数仪。当与微流体通道集成时，背面照明提高了器件级的分辨率和对比度，消除了表面处理。进一步在系统级实现了基于单帧机器学习的超分辨率处理，以最少的硬件资源实现分辨率校正。所展示的微流控细胞仪可以检测CBC中所需的血小板细胞（< 2 μ m），因此有望用于即时诊断。
Based on a 3.2-Megapixel 1.1-mu m-pitch superresolution (SR) CMOS image sensor in a 65-nm backsideillumination process, a lens-free microfluidic cytometer for complete blood count (CBC) is demonstrated in this paper. Backside-illumination improves resolution and contrast at the device level with elimination of surface treatment when integrated with microfluidic channels. A single-frame machine-learningbased SR processing is further realized at system level for resolution correction with minimum hardware resources. The demon-stratedmicrofluidic cytometer can detect the platelet cells (< 2 mu m) required in CBC, hence is promising for point-of-care diagnostics.