Osteoblastic and chondroblastic response to a variety of locally administered immunomodulators in mice.
Osteoblastic and chondroblastic response to a variety of locally administered immunomodulators in mice.
复制标题
小鼠中各种局部施用免疫调节剂的成骨细胞和软骨细胞反应。
作者：
K. Włodarski;K. Galus
直接或间接激活淋巴细胞的免疫调节剂(卡介苗、刀豆蛋白A、卡拉胶IV、葡聚糖、PHA-M、脉宽调制、棒状杆菌脂多糖)对局部骨骼有双重作用，既刺激骨膜形成，又刺激骨吸收，以前者为主。这些影响的频率和程度各不相同，在完全弗氏佐剂中给予刀豆蛋白A和卡介苗后，观察到对骨膜骨形成的最有效刺激。卡介苗在体内也是骨吸收的强诱导剂。刀豆球蛋白A和其他免疫调节剂应用于耳廓皮下时，也诱导了软骨膜软骨形成。这些免疫调节剂的新作用可应用于骨组织再生领域。
Administration into mouse shank muscles of various immunomodulators which directly or indirectly activate lymphocytes (BCG, Con A, Carrageenan IV, Dextran, PHA-M, PWM, lipopolysaccharides from Corynebacterium) have a dual effect on local bones, stimulating both periosteal bone formation and bone resorption, the former being dominant. These effects vary in frequency and magnitude, the most potent stimulation of periosteal bone formation being observed after administration of Con A and BCG in complete Freund adjuvant. BCG was also a strong inducer of bone resorption in vivo. Concanavalin A and, to a lesser degree, other immunomodulators applied, when administered subcutaneously into the pinna, also have induced perichondrial chondrogenesis. These novel effects of immunodulators could be applied in the field of skeletal tissues regeneration.