Whole-body magnetization transfer contrast imaging
Whole-body magnetization transfer contrast imaging
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DOI：
10.1002/jmri.20754
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发表时间：
2006-11-01
影响因子：
4.4
通讯作者：
Schick, Fritz
中科院分区：
文献类型：
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作者：
Boss, Andreas;Martirosian, Petros;Schick, Fritz
目的：证明全身磁化传递（MT）对比成像的可行性。材料和方法：对8名健康志愿者和5名患者进行全身MT成像（平均年龄= 40.5 +/- 17.8岁），诊断为皮肌炎（N = 1），B症状伴疑似副肿瘤疾病（N = 1），转移性恶性黑色素瘤（N = 1），和多发性硬化（MS）（N = 2）。在能够并行接收信号的1.5特斯拉全身MR扫描仪上进行测量。三维（3D）梯度回波序列（TR = 17毫秒，TE = 4.8毫秒，翻转角= 10度）与以500度有效翻转角在1.500 Hz的非共振下作用的高斯非共振NIT准备脉冲组合应用。从五个不同的身体regions.Results构建全身图像：在所有科目，全身NIT对比度图像测量时间在不到20分钟内获得。图像显示出足够的诊断图像质量，以评估患者的病理。NIT比率（MTR，单位为百分比）如下：白色物质（WM）51.1 +/- 1.0，灰质（GM）42.2 +/- 1.3，骨骼肌（四个肌肉群的平均值）50.3 +/- 2.1，肝脏39.4 +/- 3.2，脾脏31.8 +/- 2.6，肾皮质30.4 +/- 1.9，肾髓质25.6 +/- 1.3。病理类型的MTR分别为：皮肌炎骨骼肌30，恶性黑色素瘤转移30.7-36.0，子宫肌瘤49.3，MS病变30- 40。我们的初步数据表明，全身MRI中的W对比度是可行的，并且可能用于快速全身评估在NIT成像中表现出高对比度的疾病，如NIS和肌肉疾病。
Purpose: To demonstrate the feasibility of whole-body magnetization transfer (MT) contrast imaging.Materials and Methods: Whole-body MT imaging was performed on eight healthy volunteers and five patients (mean age = 40.5 +/- 17.8 years) with diagnoses of dermatomyositis (N = 1), B-symptoms with suspicion of paraneoplastic disease (N = 1), metastatic malignant melanoma (N = 1), and multiple sclerosis (MS) (N = 2). Measurements were carried out on a 1.5-Tesla whole-body MR scanner capable of parallel signal reception. A three-dimensional (3D) gradient-echo sequence (TR = 17 msec, TE = 4.8 msec, flip angle = 10 degrees) was applied in combination with a Gaussian off-resonance NIT preparation pulse acting at an off-resonance of 1.500 Hz with a 500 degrees effective flip angle. Whole-body images were constructed from five different body regions.Results: In all subjects, whole-body NIT contrast images were obtained within less than 20 minutes of measuring time. The images showed sufficient diagnostic image quality to assess the patients' pathologies. The NIT ratios (MTRs, in percent units) for the volunteers were as follows: white matter (WM) 51.1 +/- 1.0, gray matter (GM) 42.2 +/- 1.3, skeletal muscle (mean value of four muscle groups) 50.3 +/- 2.1, liver 39.4 +/- 3.2, spleen 31.8 +/- 2.6, renal cortex 30.4 +/- 1.9, and renal medulla 25.6 +/- 1.3. The MTRs for the pathologies were as follows: skeletal muscle in dermatomyositis similar to 30, metastases in malignant melanoma 30.7-36.0, uterus myoma 49.3, and MS lesions 30-40.Conclusion: Our preliminary data indicate that W contrast in whole-body MRI is feasible, and may be useful for rapid whole-body assessment of diseases that exhibit high contrast in NIT imaging, such as NIS and muscular disorders.