A new drug delivery system using plasma-irradiated pharmaceutical aids. IX. Controlled-release of theophylline from double-compressed tablet composed of cellulose derivatives as wall material.
A new drug delivery system using plasma-irradiated pharmaceutical aids. IX. Controlled-release of theophylline from double-compressed tablet composed of cellulose derivatives as wall material.
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一种使用等离子体辐照药物辅助剂的新型药物输送系统。
DOI：
10.1248/cpb.49.1615
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发表时间：
2001
影响因子：
1.7
通讯作者：
M. Kuzuya
中科院分区：
文献类型：
--
作者：
K. Ito;S. Kondo;M. Kuzuya
以水溶性高分子羟丙基甲基纤维素（HPMC）或羟丙基甲基纤维素邻苯二甲酸酯（HPMCP）为壁材的茶碱双层压片，经氩等离子体照射后，由于外层溶解度降低，可抑制其快速释放，并转变为缓释系统。结果表明，释放曲线可以变化，从而导致茶碱以不同的速率释放，这取决于为片剂生产和等离子体操作选择的一组条件。
The rapid release from a double-compressed tablet containing theophylline with the water-soluble polymer, hydroxypropylmethylcellulose (HPMC) or hydroxypropylmethylcellulose phthalate (HPMCP), used as a wall material can be suppressed by argon plasma-irradiation and changed into the sustained-release system due to a decrease in solubility of the outer layer. It was shown that the release profiles can be varied so as to cause theophylline release at different rates, depending on the set of conditions chosen for tablet manufacture and for plasma operation.
等离子体化学在药物工程中的应用
DOI：
--
发表时间：
2004
期刊：
Seidennki Gakkaishi 28(2)
影响因子：
--
作者：
福森義信;M.Kuzuya
通讯作者：
M.Kuzuya