The Effect of Diagnosis, Age, and Symptom Severity on Cortical Surface Area in the Cingulate Cortex and Insula in Autism Spectrum Disorders
The Effect of Diagnosis, Age, and Symptom Severity on Cortical Surface Area in the Cingulate Cortex and Insula in Autism Spectrum Disorders
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DOI：
10.1177/0883073812451496
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发表时间：
2013-06-01
影响因子：
1.9
通讯作者：
Anagnostou, Evdokia
中科院分区：
文献类型：
--
作者：
Doyle-Thomas, Krissy A. R.;Kushki, Azadeh;Anagnostou, Evdokia
据报道，在自闭症谱系障碍的社会任务中，前扣带皮层和前扣带皮层的功能活动是异常的。然而，很少有研究检查这些区域的表面形态学，以及这可能与自闭症谱系障碍相关。在这项研究中，27名自闭症谱系障碍患者和25名年龄在7至39岁之间的对照者接受了结构磁共振成像。我们的初步分析检查了扣带和扣带回表面积的差异，患有和没有自闭症谱系障碍的个体之间，以及与年龄相关的变化和与社会障碍的关联。右扣带回的表面积在各组之间有显著差异，并且在自闭症谱系障碍参与者中随着年龄的增长而下降得更快。此外，更大的表面积在丘脑和峡部与较差的社会行为。研究结果表明，非典型的表面形态在大脑区域参与社会功能，这似乎与社会能力较差的分数。
Functional activity in the anterior cingulate cortex and insula has been reported to be abnormal during social tasks in autism spectrum disorders. However, few studies have examined surface morphometry in these regions and how this may be related to autism spectrum disorder symptomatology. In this study, 27 individuals with autism spectrum disorders and 25 controls between the ages of 7 to 39 years underwent structural magnetic resonance imaging. Our primary analysis examined differences in surface area in the cingulate and insula, between individuals with and without autism spectrum disorders, as well as age-related changes and associations with social impairments. Surface area in the right cingulate was significantly different between groups and decreased more rapidly with age in autism spectrum disorder participants. In addition, greater surface area in the insula and isthmus was associated with poorer social behaviors. Results suggest atypical surface morphometry in brain regions involved in social function, which appeared to be related to poorer social ability scores.