Error Signals in Motor Cortices Drive Adaptation in Reaching
Error Signals in Motor Cortices Drive Adaptation in Reaching
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DOI：
10.1016/j.neuron.2016.04.029
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发表时间：
2016-06-01
期刊：
影响因子：
16.2
通讯作者：
Kitazawa, Shigeru
中科院分区：
文献类型：
--
作者：
Inoue, Masato;Uchimura, Motoaki;Kitazawa, Shigeru
到达动作会根据棱镜或外部扰动引起的误差进行调整。运动皮质回路被假设提供驱动适应的执行错误，但迄今为止的人类成像研究报告说，执行错误被编码在顶叶关联区域中。因此，几乎没有发现支持运动假说的证据。在这里，我们表明初级运动皮层和前运动皮层都编码有关到达终点错误的信息。我们进一步表明，对这些区域的运动后微刺激会导致错误不断增加，而当刺激终止时，错误会呈指数级下降。结果首次表明，运动皮层回路提供了误差信号，驱动着伸手动作中的反复试验适应。
Reaching movements are subject to adaptation in response to errors induced by prisms or external perturbations. Motor cortical circuits have been hypothesized to provide execution errors that drive adaptation, but human imaging studies to date have reported that execution errors are encoded in parietal association areas. Thus, little evidence has been uncovered that supports the motor hypothesis. Here, we show that both primary motor and premotor cortices encode information on end-point errors in reaching. We further show that post-movement microstimulation to these regions caused trial-by-trial increases in errors, which subsided exponentially when the stimulation was terminated. The results indicate for the first time that motor cortical circuits provide error signals that drive trial-by-trial adaptation in reaching movements.