Coffee intake and risk of type 2 diabetes: the Multiethnic Cohort.
Coffee intake and risk of type 2 diabetes: the Multiethnic Cohort.
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DOI：
10.1017/s1368980013000487
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发表时间：
2014-06
影响因子：
3.2
通讯作者：
Maskarinec, Gertraud
中科院分区：
文献类型：
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作者：
Doo, Taisha;Morimoto, Yukiko;Steinbrecher, Astrid;Kolonel, Laurence N.;Maskarinec, Gertraud
我们评估了夏威夷多种族队列 (MEC) 中咖啡消费对糖尿病发病率的影响。未来的队列。基于居住在夏威夷的人口样本。排除后，75,140 名 45-75 岁的白人、日裔美国人和夏威夷原住民血统的男性和女性参与了本次分析。所有参与者通过食物频率调查问卷提供有关饮食和生活方式的信息。经过 14 年的跟踪，通过自我报告、药物问卷和健康计划联系，确定了 8,582 例糖尿病病例。使用 Cox 回归计算风险比 (HR) 和 95% 置信区间 (95%CI)，同时调整已知协变量。与咖啡总消耗量相关的糖尿病风险因性别而异（Pinteraction<0.0001）。每天饮用任何类型咖啡 ≥3 杯的女性的风险显着低于那些报告 <1 杯的女性（HR：0.66；95%CI：0.58，0.77；Ptrend<0.0001），而男性的相关性则处于边缘状态（HR：0.89；95%CI：0.80，0.99；Ptrend=0.09）。普通咖啡也存在同样的性别差异，男性和女性的 HR 分别为 0.65 (95% CI: 0.54, 0.78; Ptrend<0.0001) 和 0.86 (95% CI: 0.75, 0.98; Ptrend=0.09)。对于女性（HR：0.85；95％CI：0.72，1.01；Ptrend = 0.73）或男性（HR：1.07；95％CI：0.93，1.23；Ptrend = 0.71），无咖啡因咖啡与糖尿病没有明显关联。尽管种族差异很小，但咖啡摄入量和种族之间的相互作用并不显着。在这个多种族人群中，定期摄入咖啡（但不不含咖啡因）对所有种族的女性比男性更能预防糖尿病。
We evaluated the influence of coffee consumption on diabetes incidence among the Hawaii component of the Multiethnic Cohort (MEC). Prospective cohort. Population-based sample residing in Hawaii. After exclusions, 75,140 men and women of Caucasian, Japanese American, and Native Hawaiian ancestry aged 45–75 were part of this analysis. All participants provided information on diet and lifestyle through a food frequency questionnaire. After 14 years of follow-up 8,582 incident diabetes cases were identified using self-reports, medication questionnaires, and health plan linkages. Hazard ratios (HR) and 95% confidence intervals (95%CI) were calculated using Cox regression while adjusting for known covariates. The risk for diabetes associated with total coffee consumption differed by sex (Pinteraction<0.0001). Women consuming ≥3 cups/day of any type of coffee had a significantly lower risk (HR: 0.66; 95%CI: 0.58, 0.77; Ptrend<0.0001) than those reporting <1 cup, whereas the relation in men was borderline (HR: 0.89; 95%CI: 0.80, 0.99; Ptrend=0.09). The same difference by sex was seen for regular coffee with HRs of 0.65 (95%CI: 0.54, 0.78; Ptrend<0.0001) and 0.86 (95%CI: 0.75, 0.98; Ptrend=0.09) in men and women, respectively. No significant association with diabetes was apparent for decaffeinated coffee in women (HR: 0.85; 95%CI: 0.72, 1.01; Ptrend=0.73) or men (HR: 1.07; 95%CI: 0.93, 1.23; Ptrend=0.71). Despite small differences by ethnicity, the interaction terms between coffee intake and ethnicity were not significant. In this multiethnic population, regular, but not decaffeinated, coffee intake was much more protective against diabetes in women of all ethnic groups than in men.