P53 status as a predictive biomarker for patients receiving neoadjuvant radiation-based treatment: a meta-analysis in rectal cancer.
P53 status as a predictive biomarker for patients receiving neoadjuvant radiation-based treatment: a meta-analysis in rectal cancer.
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P53 作为接受新辅助放射治疗患者的预测生物标志物的地位：直肠癌的荟萃分析
DOI：
10.1371/journal.pone.0045388
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Lu PH
中科院分区：
文献类型：
--
作者：
Chen MB;Wu XY;Yu R;Li C;Wang LQ;Shen W;Lu PH
背景：关于直肠癌患者p53状态与新辅助放疗反应之间的关系，许多研究得出了不一致的结果。我们进行了一项荟萃分析，以阐明p53状态与直肠癌放射治疗反应之间的关系。方法/结果：共确定了30项先前发表的合格研究，包括1，830例病例，并纳入本荟萃分析。在接受新辅助放射治疗的直肠癌患者中，野生型p53状态（p53蛋白和/或野生型p53基因的低表达）与病理反应相关（良好反应：风险比[RR]= 1.30; 95%置信区间[CI]= 1.14-1.49; p<0.001;完全反应RR = 1.65; 95% CI = 1.19-2.30; p = 0.003;不良反应RR = 0.85; 95% CI = 0.75-0.96; p = 0.007）。 在进一步的分层分析中，新辅助放疗（RT）环境中的良好和不良反应亚组以及放化疗（CRT）环境中的良好和完全反应亚组仍然存在这种相关性。p53基因突变与疗效的相关性强于p53蛋白阳性与疗效的相关性。结论P53状态是直肠癌新辅助放疗疗效的预测因子。
Background Numerous studies have yielded inconsistent results regarding the relationship between p53 status and the response to neoadjuvant radiation-based therapy in patients with rectal cancer. We conducted a meta-analysis to clarify the relationship between p53 status and response to radiation-based therapy in rectal cancer. Methods/Findings A total of 30 previously published eligible studies including 1,830 cases were identified and included in this meta-analysis. Wild-type form of p53 status (low expression of p53 protein and/or wild-type p53 gene) was associated with pathologic response in rectal cancer patients who received neoadjuvant radiation-based therapy (good response: risk ratio [RR] = 1.30; 95% confidence intervals [CI] = 1.14–1.49; p<0.001; complete response RR = 1.65; 95% CI = 1.19–2.30; p = 0.003; poor response RR = 0.85; 95% CI = 0.75–0.96; p = 0.007). In further stratified analyses, this association remained for sub-groups of good and poor response in neoadjuvant radiotherapy (RT) setting, good and complete response in chemoradiotherapy (CRT) setting. And the association between response and the presence of p53 gene mutations was stronger than that between response and protein positivity. Conclusion The results of the present meta-analysis indicate that P53 status is a predictive factor for response in rectal cancer patient undergoing neoadjuvant radiation-based therapy.
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影响因子：
158.5
作者：
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通讯作者：
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影响因子：
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DOI：
10.1016/j.ijrobp.2010.05.025
发表时间：
2010-11-01
影响因子：
7
作者：
Chen, Miao-Fen;Lee, Kuan-Der;Wang, Jeng-Yi
通讯作者：
Wang, Jeng-Yi