NEUREGULIN 1/ErbB4 ENHANCES SYNCHRONIZED OSCILLATIONS OF PREFRONTAL CORTEX NEURONS VIA INHIBITORY SYNAPSES
NEUREGULIN 1/ErbB4 ENHANCES SYNCHRONIZED OSCILLATIONS OF PREFRONTAL CORTEX NEURONS VIA INHIBITORY SYNAPSES
复制标题
神经调节蛋白 1/ErbB4 通过抑制性突触增强前额皮层神经元的同步振荡
DOI：
10.1016/j.neuroscience.2013.12.040
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发表时间：
2014-03-07
期刊：
影响因子：
3.3
通讯作者：
Li, X. -M.
中科院分区：
文献类型：
--
作者：
Hou, X. -J.;Ni, K. -M.;Li, X. -M.
神经调节蛋白1（NRG 1）及其受体ErbB 4是精神分裂症的易感基因。在几个皮层区域，特别是在前额叶皮层，诱发振荡的同步性降低与精神分裂症的核心症状有关。最近的研究报道NRG 1可能影响海马振荡。然而，NRG 1/ErbB 4信号在前额叶皮层神经元同步化中的作用尚不清楚。在这里，我们发现NRG 1通过突触前中间神经元增强锥体神经元的同步性。同时，NRG 1还增强了前额叶皮层中快速发放中间神经元对之间以及快速发放和非快速发放中间神经元对之间的同步性，这种作用是通过ErbB 4受体介导的。此外，NRG 1增强的中间神经元的同步性是通过它们的相互抑制的突触，而不是电耦合。此外，红藻氨酸诱导的γ振荡在体内被NRG 1增强，并且在Dlx 5/6-ErbB 4（-/-）小鼠中没有改变，其中ErbB 4受体在额叶脑的中间神经元中被特异性敲除。总的来说，我们的研究结果表明，NRG 1/ErbB 4信号在精神分裂症患者受损的前额叶皮层整个网络的同步振荡中起着重要作用。(C)2013年IBRO。由爱思唯尔有限公司出版。保留所有权利。
Both neuregulin 1 (NRG1) and its receptor ErbB4 are susceptibility genes for schizophrenia. Reduced synchronization of evoked oscillations in several cortical regions, especially in the prefrontal cortex, is associated with the core symptoms of schizophrenia. Recent studies have reported that NRG1 may affect the hippocampal oscillations. However, the role of NRG1/ErbB4 signaling in the synchronization of neurons in the prefrontal cortex is unclear. Here, we found that NRG1 enhanced the synchrony of pyramidal neurons via presynaptic interneurons. Mean-while, NRG1 also increased the synchrony between pairs of fast-spiking interneurons and pairs of fast-spiking and non-fast-spiking interneurons in the prefrontal cortex, and this effect was mediated by ErbB4 receptors. Moreover, the NRG1-enhanced synchrony of interneurons was through their mutually-inhibitory synapses but not electrical coupling. Furthermore, kainate-induced gamma oscillations in vivo were enhanced by NRG1 and did not change in Dlx5/6-ErbB4(-/-) mice in which the ErbB4 receptors were specifically knocked out in interneurons of the frontal brain. Overall, our findings suggested that NRG1/ErbB4 signaling plays an important role in the synchronized oscillations of the whole network in the prefrontal cortex that are impaired in schizophrenia. (C) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.