Mechanical adaptation of trabecular bone morphology in the mammalian mandible.
Mechanical adaptation of trabecular bone morphology in the mammalian mandible.
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DOI：
10.1038/s41598-018-25597-0
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发表时间：
2018-05-08
影响因子：
4.6
通讯作者：
Gröning F
中科院分区：
文献类型：
--
作者：
Watson PJ;Fitton LC;Meloro C;Fagan MJ;Gröning F
牙槽骨和其下的骨小梁在提供抗咀嚼力的结构支持方面起着重要的作用。骨质疏松症或牙周炎等疾病会引起牙槽骨吸收，从而削弱这种结构支持，是牙齿脱落的主要原因。然而，磨牙区牙槽骨重塑与咀嚼力之间的功能关系尚不清楚。本研究通过比较不同饮食和功能负荷的哺乳动物物种（猫科动物、尾鹿、智人、scrofa、小丘羊、羊）来研究这一关系。我们进行了骨小梁形态的组织形态学分析（骨体积分数、骨小梁厚度和骨小梁间距），并量化了骨和牙根体积沿牙排的变化。主成分分析和非参数方差分析显示，不同功能负荷的物种之间的骨小梁形态存在统计学差异，但这些差异在亚成年标本中未见。我们的研究结果支持咀嚼功能和小梁骨形态之间强大而复杂的联系。进一步了解潜在的功能关系有助于诊断和治疗引起牙槽骨吸收的下颌疾病，并指导种植体的设计和评估。
Alveolar bone, together with the underlying trabecular bone, fulfils an important role in providing structural support against masticatory forces. Diseases such as osteoporosis or periodontitis cause alveolar bone resorption which weakens this structural support and is a major cause of tooth loss. However, the functional relationship between alveolar bone remodelling within the molar region and masticatory forces is not well understood. This study investigated this relationship by comparing mammalian species with different diets and functional loading (Felis catus, Cercocebus atys, Homo sapiens, Sus scrofa, Oryctolagus cuniculus, Ovis aries). We performed histomorphometric analyses of trabecular bone morphology (bone volume fraction, trabecular thickness and trabecular spacing) and quantified the variation of bone and tooth root volumes along the tooth row. A principal component analysis and non-parametric MANOVA showed statistically significant differences in trabecular bone morphology between species with contrasting functional loading, but these differences were not seen in sub-adult specimens. Our results support a strong, but complex link between masticatory function and trabecular bone morphology. Further understanding of a potential functional relationship could aid the diagnosis and treatment of mandibular diseases causing alveolar bone resorption, and guide the design and evaluation of dental implants.
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影响因子：
3
作者：
Daegling, DJ
通讯作者：
Daegling, DJ
影响因子：
4.3
作者：
Cordaro, L;Amadè, DS;Cordaro, M
通讯作者：
Cordaro, M
影响因子：
3.5
作者：
Brennan, David S.;Spencer, A. John;Roberts-Thomson, Kaye F.
通讯作者：
Roberts-Thomson, Kaye F.
影响因子：
--
作者：
FROST, HM
通讯作者：
FROST, HM
影响因子：
3.6
作者：
Antonio Gil-Montoya, Jose;Ferreira de Mello, Ana Lucia;Bravo, Manuel
通讯作者：
Bravo, Manuel