A missing member of conjugated N-heterocycles: realizing pyrido[1,2-alpha]azepine by reacting ruthenium alkenylcarbene complex with alkyne
A missing member of conjugated N-heterocycles: realizing pyrido[1,2-alpha]azepine by reacting ruthenium alkenylcarbene complex with alkyne
复制标题
共轭N-杂环的缺失成员：通过钌烯基卡宾络合物与炔反应实现吡啶并[1,2-α]氮杂
DOI：
10.1039/c8cc00758f
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发表时间：
2018
影响因子：
4.9
通讯作者：
Xia Haiping
中科院分区：
文献类型：
--
作者：
Zhou Xiaoxi;Huang Fanping;Tang Chun;Zhuo Qingde;Chen Zhixin;Zhang Hong;Xia Haiping
尽管N-杂环化合物具有优异的化学性质，但吡啶并[1，2-α]氮杂环由于其潜在的抗芳香性和稳定性而一直难以捉摸。在这里，我们展示了第一个利用Ru中心配位来促进N-桥自行车稳定性的双环吡啶并[1，2-α]氮杂环丙烷的合成和表征。
Despite the excellent chemical properties of N-heterocycles, pyrido[1,2-α]azepine remains elusive due to its potential antiaromaticity and lability. Herein, we demonstrate the synthesis and characterization of the first bicyclic pyrido[1,2-α]azepine that leverages the coordination to the ruthenium center to promote the stability of N-bridged bicycle.