Pattern recognition receptors and their role in invasive aspergillosis
Pattern recognition receptors and their role in invasive aspergillosis
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DOI：
10.1111/j.1749-6632.2012.06759.x
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发表时间：
2012-01-01
期刊：
影响因子：
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通讯作者：
van de Veerdonk, Frank L.
中科院分区：
文献类型：
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作者：
Gresnigt, Mark S.;Netea, Mihai G.;van de Veerdonk, Frank L.
模式识别受体（PRRs）是一种能够识别微生物保守结构的种系受体。近年来已经发现了几种与烟曲霉免疫应答有关的PRRs。在宿主免疫功能低下的情况下，PRRs在侵袭性肺曲霉病中的作用尤为明显，因为宿主防御烟曲霉的过程中存在许多PRRs。对侵袭性曲霉病中PRRs及其效应途径的研究使我们对免疫功能低下患者侵袭性曲霉病的发病机制有了更好的了解。这一知识可能为新的诊断和免疫调节治疗策略铺平道路，这些策略需要克服免疫功能低下患者与侵袭性烟曲霉感染相关的高死亡率。
Pattern recognition receptors (PRRs) are germline receptors that recognize conserved structures on microorganisms. Several PRRs have been identified in the recent years that are involved in the immune response against Aspergillus fumigatus. The role of PRRs in invasive pulmonary aspergillosis becomes especially apparent in the setting of an immunocompromised status of the host because of the redundancy of many PRRs in the host defense against A. fumigatus. Studies that investigated the PRRs and their effector pathways in invasive aspergillosis have led to a better understanding of the pathogenesis of invasive aspergillosis in immunocompromised patients. This knowledge may pave the way for novel diagnostic and immunomodulatory treatment strategies that are needed to overcome the high mortality associated with invasive A. fumigatus infection in immunocompromised patients.