The role of cell death in the pathogenesis of autoimmune disease: HMGB1 and microparticles as intercellular mediators of inflammation.
The role of cell death in the pathogenesis of autoimmune disease: HMGB1 and microparticles as intercellular mediators of inflammation.
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DOI：
10.1007/s10165-008-0054-z
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发表时间：
2008
影响因子：
2.2
通讯作者：
Pisetsky, David S.
中科院分区：
文献类型：
--
作者：
Ardoin, Stacy P.;Pisetsky, David S.
细胞死亡对于正常的体内平衡是至关重要的，尽管当这个过程异常增加时，可以导致促炎介质的产生，从而促进自身免疫。在细胞死亡过程中产生的两种新的细胞间炎症介质是高迁移率族蛋白1（HMGB1）蛋白和微粒（MP）。HMGB1是一种核蛋白，当在细胞核内时在转录中起作用，但当在细胞死亡期间释放时具有促炎特性。微粒是细胞死亡时从细胞中挤出的小的、膜结合的结构，并且含有来自其亲本细胞的细胞表面蛋白质和核物质。MP在整个脉管系统中广泛循环，并介导细胞之间的长距离通信。MP和HMGB1都与广谱炎性疾病的发病机制有关，包括原型自身免疫性疾病系统性红斑狼疮和类风湿性关节炎。鉴于它们的活性范围和与活动性疾病的相关性，这两种结构可能被证明是这些和其他疾病的有效治疗靶点。
Cell death is critical to normal homeostasis, although this process, when increased aberrantly, can lead to the production of pro-inflammatory mediators promoting autoimmunity. Two novel intercellular mediators of inflammation generated during cell death are high mobility group box 1 (HMGB1) protein and microparticles (MPs). HMGB1 is a nuclear protein that functions in transcription when inside the nucleus but takes on pro-inflammatory properties when released during cell death. Microparticles are small, membrane-bound structures that extrude from cells when they die and contain cell surface proteins and nuclear material from their parent cells. MPs circulate widely throughout the vasculature and mediate long-distance communication between cells. Both MPs and HMGB1 have been implicated in the pathogenesis of a broad spectrum of inflammatory diseases, including the prototypic autoimmune conditions systemic lupus erythematosus and rheumatoid arthritis. Given their range of activity and association with active disease, both structures may prove to be targets for effective therapy in these and other disorders.
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影响因子：
30.8
作者：
Calogero, S;Grassi, F;Bianchi, ME
通讯作者：
Bianchi, ME
影响因子：
7.2
作者：
Distler, JHW;Huber, LC;Pisetsky, DS
通讯作者：
Pisetsky, DS
DOI：
10.1083/jcb.137.1.19
发表时间：
1997-04-07
期刊：
The Journal of cell biology
影响因子：
--
作者：
Falciola L;Spada F;Calogero S;Langst G;Voit R;Grummt I;Bianchi ME
通讯作者：
Bianchi ME
影响因子：
5.5
作者：
Bell, Charles W.;Jiang, Weiwen;Pisetsky, David S.
通讯作者：
Pisetsky, David S.
影响因子：
2.6
作者：
Baj-Krzyworzeka, M;Majka, M;Ratajczak, MZ
通讯作者：
Ratajczak, MZ