Effects of endotoxic shock on right ventricular systolic function and mechanical efficiency
Effects of endotoxic shock on right ventricular systolic function and mechanical efficiency
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DOI：
10.1016/s0008-6363(03)00368-7
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发表时间：
2003-08-01
影响因子：
10.8
通讯作者：
D'Orio, V
中科院分区：
文献类型：
--
作者：
Lambermont, B;Ghuysen, A;D'Orio, V
目的：探讨内毒素对右心室收缩功能和机械效率的影响。研究方法：6只麻醉猪（Endo组）在30 min内接受0.5 mg/kg内毒素输注，并与接受安慰剂5 h的其他6只麻醉猪（对照组）进行比较。采用电导导管技术获得右心室压力-容积（PV）环，并采用高保真换能器测量肺动脉流量和压力。结果如下：在内毒素诱导的肺动脉高压早期（T30），右心室对后负荷增加的适应性变化是通过等时和等时调节获得的：右心室收缩末期PV关系的斜率从1.4 ± 0.2mmHg/ml增加到2.9 ± 0.4mmHg/ml（P
Objective: To investigate the effects of endotoxin infusion on right ventricular (RV) systolic function and mechanical efficiency. Methods: Six anesthetized pigs (Endo group) received a 0.5 mg/kg endotoxin infusion over 30 min and were compared with six other anesthetized pigs (Control group) receiving placebo for 5 h. RV pressure-volume (PV) loops were obtained by the conductance catheter technique and pulmonary artery flow and pressure were measured with high-fidelity transducers. Results: RV adaptation to increased afterload during the early phase of endotoxin-induced pulmonary hypertension (T30) was obtained by both homeometric and hetereometric regulations: the slope of the end-systolic PV relationship of the right ventricle increased from 1.4+/-0.2 mmHg/ml to 2.9+/-0.4 mmHg/ml (P