A somatosensory cortex input to the caudal dorsolateral striatum controls comorbid anxiety in persistent pain
A somatosensory cortex input to the caudal dorsolateral striatum controls comorbid anxiety in persistent pain
复制标题
尾部背外侧纹状体的体感皮层输入控制持续性疼痛中的共病焦虑
DOI：
10.1097/j.pain.0000000000001724
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发表时间：
2020-02-01
期刊：
影响因子：
7.4
通讯作者：
Zhang, Zhi
中科院分区：
文献类型：
--
作者：
Jin, Yan;Meng, Qian;Zhang, Zhi
慢性疼痛和焦虑症状在临床上是常见的，但慢性疼痛引起的共病疼痛焦虑症状(CASP)的神经回路机制尚不清楚。利用病毒对小鼠神经元的示踪，我们发现了一条未知的通路，即从后肢初级体感皮质(S1)第5层的谷氨酸能神经元(Glu(S1))投射到尾侧背外侧纹状体(GABA，CDLS)的GABA能神经元。Glu(S1)是一个众所周知的参与疼痛处理的脑区。在完全弗氏佐剂注射诱导的持续性炎性疼痛模型中，CASP小鼠的Glu(S1)->；GABA(CDLS)通路兴奋增强。使用化学遗传或光遗传方法逆转这一途径可以缓解CASP。此外，CDLS中Glu(S1)终末的光学激活在幼小鼠中产生了类似焦虑的行为。总体而言，目前的研究表明，一个新的Glu(S1)->；GABA(CDLS)通路在控制CASP的至少某些方面具有假定的重要性。
Chronic pain and anxiety symptoms are frequently encountered clinically, but the neural circuit mechanisms underlying the comorbid anxiety symptoms in pain (CASP) in context of chronic pain remain unclear. Using viral neuronal tracing in mice, we identified a previously unknown pathway whereby glutamatergic neurons from layer 5 of the hindlimb primary somatosensory cortex (S1) (Glu(S1)), a well-known brain region involved in pain processing, project to GABAergic neurons in the caudal dorsolateral striatum (GABA(cDLS)). In a persistent inflammatory pain model induced by complete Freund's adjuvant injection, enhanced excitation of the Glu(S1)-> GABA(cDLS) pathway was found in mice exhibiting CASP. Reversing this pathway using chemogenetic or optogenetic approaches alleviated CASP. In addition, the optical activation of Glu(S1) terminals in the cDLS produced anxiety-like behaviors in naive mice. Overall, the current study demonstrates the putative importance of a novel Glu(S1)-> GABA(cDLS) pathway in controlling at least some aspects of CASP.