Scaling up Metal Scavenging Operations for Pharmaceutical Pilot Plant Manufactures
Scaling up Metal Scavenging Operations for Pharmaceutical Pilot Plant Manufactures
复制标题
扩大制药中试工厂制造的金属清除操作
DOI：
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
R. Wilkes
中科院分区：
文献类型：
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作者：
G. Reginato;P. Sadler;R. Wilkes
用于选择性去除工艺流中的金属杂质的功能化二氧化硅被包装在滤筒中并插入多筒过滤器中。催化反应之后的清除步骤涉及工艺流以预定的线速度和温度单次通过多芯过滤器装置。到目前为止，在几十公斤的规模上，金属还原效率高达98%。此外，锚定在清除剂官能团上的贵金属可以回收和精炼。描述了我们按时间顺序开发的一种多功能、通用且易于扩展的工艺规模金属清除格式，并通过真实的时间应用于通过我们的制药中试工厂的一系列项目，采用各种金属（钯、铑、铱）进行说明。还初步评估了墨盒格式在经济和环境影响方面的好处。
Functionalised silicas, used for selectively removing metal impurities in process streams, are packed in cartridges and inserted into multicartridge filters. The scavenging step that follows a catalytic reaction involves the single pass of the process stream through the multicartridge filter setup at a predetermined linear velocity and temperature. Efficiency in metal reduction as high as 98% has been so far achieved at tens of kilograms scale. Furthermore, the precious metal anchored onto the scavenger’s functionalities can be recovered and refined. Our chronological development of a versatile, general, and easily scalable format for metal scavenging at process scales is described, illustrated by application in real time to a range of projects passing through our Pharmaceutical Pilot Plant, employing a variety of metals (palladium, rhodium, iridium). Benefits of the cartridge format in terms of economics and environmental impact are also initially assessed.