AGED RATS ARE STILL RESPONSIVE TO THE ANTIDEPRESSANT AND MEMORY-IMPROVING EFFECTS OF OXYTOCIN
AGED RATS ARE STILL RESPONSIVE TO THE ANTIDEPRESSANT AND MEMORY-IMPROVING EFFECTS OF OXYTOCIN
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DOI：
10.1016/0143-4179(95)90021-7
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发表时间：
1995-09-01
期刊：
影响因子：
2.9
通讯作者：
BERTOLINI, A
中科院分区：
文献类型：
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作者：
ARLETTI, R;BENELLI, A;BERTOLINI, A
在实验前60分钟腹腔注射催产素，26月龄雄性大鼠的社会记忆（剂量分别为3和6 ng/kg）得到显著改善，行为绝望实验中静止不动时间（剂量分别为50和500 μ g/kg）得到显著缩短。这些结果与先前在成年大鼠中获得的数据一致，表明衰老不会损害催产素改善社会记忆和抗抑郁的活性。
Oxytocin, intraperitoneally injected to 26-month-old male rats 60 min before testing, significantly improved social memory (at doses of 3 and 6 ng/kg) and reduced the duration of immobility in the behavioral despair test (at doses of 50 and 500 mu g/kg). These results are in agreement with previous data obtained in adult rats and indicate that aging does not compromise the social memory improving and antidepressant-like activities of oxytocin.