Angiotensin-Converting Enzyme Inhibitor Use and Incident Frailty: A Longitudinal Cohort Study.
Angiotensin-Converting Enzyme Inhibitor Use and Incident Frailty: A Longitudinal Cohort Study.
复制标题
血管紧张素转换酶抑制剂的使用和事件衰弱：一项纵向队列研究。
DOI：
10.1007/s40266-019-00642-3
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发表时间：
2019
期刊：
影响因子：
2.8
通讯作者：
Koyanagi,Ai
中科院分区：
文献类型：
--
作者：
Veronese,Nicola;Stubbs,Brendon;Smith,Lee;Maggi,Stefania;Jackson,SarahE;Soysal,Pinar;Demurtas,Jacopo;Celotto,Stefano;Koyanagi,Ai
血管紧张素转换酶抑制剂（ACEI）可能具有多种多效性，但关于ACEI的使用与虚弱之间可能的关系的文献有限。我们调查是否ACEI的使用是与较低的风险，在一个队列的脆弱的北美individuals.MethodsData从骨关节炎倡议，队列研究与8年的后续行动，包括社区居住的成年人膝关节骨关节炎或高风险，这种情况进行了分析。ACEI的使用是通过自我报告的信息定义的，并由经过培训的访谈者证实。使用骨质疏松性骨折研究（SOF）指数将虚弱定义为至少存在以下两项标准：（1）基线和任何后续随访访视之间的体重减轻≥ 5%;（2）无法进行5次椅子站立;和（3）根据SOF定义的低能量水平。多变量Poisson回归分析用于评估基线时ACEI使用与偶发虚弱之间的关联。这些数据被报告为相对危险度（RR），其95%置信区间（CI）。ResultsThe最终样本包括4295成人（平均年龄61.2岁，女性58.1%）。基线时，551名参与者（12.8%）使用ACEI。校正15个潜在混杂因素后，使用ACEI与较低的虚弱风险相关（RR 0.72; 95%CI 0.53-0.99）。调整的倾向评分基本上证实了这些发现（RR 0.75; 95%CI 0.54-0.996）。ConclusionACEI的使用可能与降低风险的个人/风险的膝关节骨关节炎的脆弱性，这表明ACI在预防脆弱性的潜在作用。
IntroductionAngiotensin-converting enzyme inhibitors (ACEI) may have several pleiotropic effects, but the literature regarding a possible relationship between ACEI use and frailty is limited. We investigated whether ACEI use is associated with lower risk of frailty in a cohort of North American individuals.MethodsData from the Osteoarthritis Initiative, a cohort study with 8 years of follow-up including community-dwelling adults with knee osteoarthritis or at high risk for this condition, were analyzed. ACEI use was defined through self-reported information and confirmed by a trained interviewer. Frailty was defined using the Study of Osteoporotic Fracture (SOF) index as the presence of at least two of the following criteria: (1) weight loss ≥ 5% between baseline and any subsequent follow-up visit; (2) inability to do five chair stands; and (3) low energy level according to the SOF definition. A multivariable Poisson regression analysis was used to assess the association between ACEI use at baseline and incident frailty. The data were reported as relative risks (RRs) with their 95% confidence intervals (CIs).ResultsThe final sample consisted of 4295 adults (mean age 61.2 years, females 58.1%). At baseline, 551 participants (12.8%) used ACEI. After adjusting for 15 potential confounders, the use of ACEI was associated with a lower risk of frailty (RR 0.72; 95% CI 0.53–0.99). The adjustment for the propensity score substantially confirmed these findings (RR 0.75; 95% CI 0.54–0.996).ConclusionACEI use may be associated with a reduced risk of frailty in individuals with/at risk of knee osteoarthritis, suggesting a potential role for ACI in the prevention of frailty.