Altered intrinsic regional brain spontaneous activity in patients with comitant strabismus: a resting-state functional MRI study.
Altered intrinsic regional brain spontaneous activity in patients with comitant strabismus: a resting-state functional MRI study.
复制标题
合并斜视患者内在区域大脑自发活动的改变：一项静息态功能性 MRI 研究
DOI：
10.2147/ndt.s105478
复制
发表时间：
2016
影响因子：
3.2
通讯作者：
Zeng XJ
中科院分区：
文献类型：
--
作者：
Huang X;Li SH;Zhou FQ;Zhang Y;Zhong YL;Cai FQ;Shao Y;Zeng XJ
目的 探讨合并斜视（CS）患者大脑活动异常的潜在区域同质性（ReHo）及其与行为表现的关系。方法 对 20 名 CS 患者（10 名男性和 10 名女性）和 20 名年龄、性别和教育程度匹配的健康对照者（10 名男性和 10 名女性）进行静息态功能磁共振成像扫描。 ReHo 方法用于评估自发大脑活动的局部特征。通过受试者工作特征曲线将 CS 患者与 HC 患者区分开来。进行相关分析来探讨观察到的不同大脑区域的平均 ReHo 值与行为表现之间的关系。结果与HCs相比，CS患者右侧颞下皮质/梭状回/小脑前叶、右侧舌回、双侧扣带回ReHo值显着升高。我们没有发现观察到的不同大脑区域的平均 ReHo 值与行为表现之间存在任何关系。结论 CS引起多个脑区功能障碍，这可能解释了CS的融合代偿现象。
Objective To investigate the underlying regional homogeneity (ReHo) of brain-activity abnormalities in patients with comitant strabismus (CS) and their relationship with behavioral performance. Methods Twenty patients with CS (ten men and ten women) and 20 (ten men and ten women) age-, sex-, and education-matched healthy controls (HCs) underwent resting-state functional magnetic resonance imaging scans. The ReHo method was used to assess local features of spontaneous brain activities. Patients with CS were distinguished from HCs by receiver operating characteristic curve. Correlation analysis was performed to explore the relationship between the observed mean ReHo values of the different brain areas and behavioral performance. Results Compared to HCs, the patients with CS showed significantly increased ReHo values in the right inferior temporal cortex/fusiform gyrus/cerebellum anterior lobe, right lingual gyrus, and bilateral cingulate gyrus. We did not find any relationship between the observed mean ReHo values of the different brain areas and behavioral performance. Conclusion CS causes dysfunction in many brain regions, which may explain the fusion compensation in CS.