Enhanced photoacoustic stability of gold nanorods by silica matrix confinement
Enhanced photoacoustic stability of gold nanorods by silica matrix confinement
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DOI：
10.1117/1.3292574
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发表时间：
2010-01-01
影响因子：
3.5
通讯作者：
Lo, Leu-Wei
中科院分区：
文献类型：
--
作者：
Chen, Leng-Chun;Wei, Chen-Wei;Lo, Leu-Wei
光声层析成像（PAT）由于其高对比度和良好的灌注组织空间分辨率而受到广泛关注。金纳米棒（GNRs）已被用于进一步增强PAT的成像对比度。然而，PA波感应通常所需的光子注量通常也导致GNR形状变化，这显著降低了声波生成的效率。在这项工作中，我们提出，合成，并评估无定形二氧化硅包覆的金纳米棒（GNR-Si），努力提高造影剂的稳定性和改善效率损失在光声（PA）波诱导。GNR和GNR-Si的TEM和光学吸收光谱测量表明，在无定形二氧化硅内包裹GNR提供了对纳米棒构象的热变形的实质性保护。由GNR-Si产生的PA信号表现出比未涂覆的GNR对重复脉冲信号强度退化的显著更大的抵抗力，从而实现比以前可能的更长的高对比度成像会话。高对比度成像的延长，以及无定形二氧化硅提供的靶向配体的生物相容性和容易的表面功能化，表明GNR-Si对PAT的临床转化具有潜在的重要意义。(C)2010年，美国光学仪器工程师学会（Society of Photo-Optical Instrumentation Engineers）[DOI 10.1117/1.3292574]
Photoacoustic tomography (PAT) has garnered much attention for its high contrast and excellent spatial resolution of perfused tissues. Gold nanorods (GNRs) have been employed to further enhance the imaging contrast of PAT. However, the photon fluences typically needed for PA wave induction often also result in GNR shape changes that significantly reduce the efficiency of acoustic wave generation. In this work, we propose, synthesize, and evaluate amorphous silica-coated gold nanorods (GNR-Si) in an effort to improve contrast agent stability and ameliorate efficiency loss during photoacoustic (PA) wave induction. TEM and optical absorption spectra measurements of GNR and GNR-Si show that encasing GNRs within amorphous silica provides substantial protection of nanorod conformation from thermal deformation. PA signals generated by GNR-Si demonstrate considerably greater resistance to degradation of signal intensity with repetitive pulsing than do uncoated GNRs, thereby enabling much longer, high-contrast imaging sessions than previously possible. The prolongation of high-contrast imaging, and biocompatibility and easy surface functionalization for targeting ligands afforded by amorphous silica, suggest GNR-Si to be potentially significant for the clinical translation of PAT. (C) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3292574]