AMYLOID PROTEIN SAA IS AN APOPROTEIN OF MOUSE PLASMA HIGH-DENSITY LIPOPROTEIN
AMYLOID PROTEIN SAA IS AN APOPROTEIN OF MOUSE PLASMA HIGH-DENSITY LIPOPROTEIN
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DOI：
10.1073/pnas.76.8.4092
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发表时间：
1979-01-01
影响因子：
11.1
通讯作者：
HANSON, RH
中科院分区：
文献类型：
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作者：
BENDITT, EP;ERIKSEN, N;HANSON, RH
小鼠血浆中含有一种与小鼠蛋白AA抗原相关的蛋白质，小鼠AA是从小鼠体内淀粉样物质的组织沉积中提取的主要蛋白质。血浆抗原SAA主要以高相对分子质量形式存在(2倍)。密度区间1.063-1.21g/cm~3(高密度脂蛋白)；绝对和相对总蛋白含量最大的是密度区间1.125-12.1g/cm~3(HDL3)。通过脱脂获得的小鼠高密度脂蛋白的载脂蛋白在酸/尿素中被层析，其抗原性出现在载脂蛋白复合体的10,000-15,000道尔顿部分。在这些特征上，小鼠SAA与人类SAA非常相似，与淀粉样蛋白AA相关的蛋白质的行为表明，它是两个物种的高密度脂蛋白复合体的载脂蛋白之一。它的建议名称是apoSAA。
Mouse plasma contains a protein antigenically related to mouse protein AA, the principal protein derived from tissue deposits of amyloid substance in mice. The plasma antigen, SAA, was found mainly as a high MW form (2 .times. 105) residing for the most part in the density interval 1.063-1.21 g/cm3 (high density lipoprotein, HDL); the largest amount of SAA, absolute and relative to total protein, was found in the density interval 1.125-12.1 g/cm3 (HDL3). When apoproteins of the mouse HDL obtained by delipidation of the lipoprotein particles were chromatographed in acid/urea, the antigenic activity appeared in the 10,000- to 15,000-dalton portion of the apoprotein complex. In these characteristics mouse SAA closely resembles human SAA and the behavior of the protein related to amyloid protein AA indicates that it is one of the apoproteins of the HDL complex in both species. Its suggested name is apoSAA.