The cell cycle and Myc intersect with mechanisms that regulate pluripotency and reprogramming.
The cell cycle and Myc intersect with mechanisms that regulate pluripotency and reprogramming.
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DOI:
10.1016/j.stem.2009.07.003
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发表时间:
2009-08-07
期刊:
影响因子:
23.9
通讯作者:
Dalton S
中科院分区:
文献类型:
--
作者:
Singh AM;Dalton S
Pluripotent stem cells have long-term proliferative capacity, an unusual mode of cell cycle regulation and can divide independently of extrinsic mitogenic signals. The last few years has seen evidence emerge that links cell cycle regulation to the maintenance and establishment of pluripotency. Myc transcription factors appear to be central to this regulation. This review addresses these links and discusses how cell cycle controls and Myc impact on the maintenance and establishment of pluripotent cells.
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