Life and death decisions by the E2F transcription factors
Life and death decisions by the E2F transcription factors
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DOI：
10.1016/j.ceb.2007.10.006
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发表时间：
2007-12-01
影响因子：
7.5
通讯作者：
Lees, Jacqueline A.
中科院分区：
文献类型：
--
作者：
Iaquinta, Phillip J.;Lees, Jacqueline A.
E2F转录因子是细胞周期适当进展所需基因的关键调节因子，并且在特殊情况下，它们还可以促进在凋亡程序中起作用的另一类基因的表达。由于E2Fs可以启动细胞增殖和细胞死亡，因此这些蛋白质的促凋亡能力受到复杂的调控并不奇怪。最近的研究使我们对E2F诱导细胞凋亡的影响因素以及E2F在此过程中的下游靶点有了更深入的了解。
The E2F transcription factors are critical regulators of genes required for appropriate progression through the cell cycle, and in special circumstances they can also promote the expression of another class of genes that function in the apoptotic program. Since E2Fs can initiate both cell proliferation and cell death, it is not surprising that the pro-apoptotic capacity of these proteins is subject to complex regulation. Recent study has expanded our knowledge of the factors influencing E2F-induced apoptosis as well as downstream targets of E2F in this process.