High-Frequency Oscillations Recorded on the Scalp of Patients With Epilepsy Using Tripolar Concentric Ring Electrodes
High-Frequency Oscillations Recorded on the Scalp of Patients With Epilepsy Using Tripolar Concentric Ring Electrodes
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DOI：
10.1109/jtehm.2014.2332994
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发表时间：
2014-01-01
影响因子：
3.4
通讯作者：
Medvedev, Andrei V.
中科院分区：
文献类型：
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作者：
Besio, Walter G.;Martinez-Juarez, Iris E.;Medvedev, Andrei V.
癫痫是第二大最常见的神经系统疾病（患病率约为1%），影响全球约6700万人，其中高达75%来自发展中国家。传统的脑电图受到来自运动、肌肉和其他来源的伪影的困扰。三极同心环电极自动衰减肌肉伪影并提供改善的信号质量。我们在健康人体中进行了基本实验，表明三极同心环电极确实可以在闭眼时记录生理α波。然后，我们进行了同步记录与传统的圆盘电极和三极同心环电极癫痫患者。我们发现，我们可以检测到高频振荡，早期癫痫发作发展和致痫区的标志，在头皮表面上，似乎在癫痫发作前变得更加窄带。癫痫发作前的高频振荡存在于三极同心环电极数据通道的平均35.5%的癫痫患者，其癫痫发作记录在相应的常规圆盘电极数据中，而不存在。平均78.2%的通道，包含高频率振荡的癫痫发作或刺激区内确定的三个癫痫科医生的基础上，传统的盘电极数据和视频独立。
Epilepsy is the second most prevalent neurological disorder (similar to 1% prevalence) affecting similar to 67 million people worldwide with up to 75% from developing countries. The conventional electroencephalogram is plagued with artifacts from movements, muscles, and other sources. Tripolar concentric ring electrodes automatically attenuate muscle artifacts and provide improved signal quality. We performed basic experiments in healthy humans to show that tripolar concentric ring electrodes can indeed record the physiological alpha waves while eyes are closed. We then conducted concurrent recordings with conventional disc electrodes and tripolar concentric ring electrodes from patients with epilepsy. We found that we could detect high frequency oscillations, a marker for early seizure development and epileptogenic zone, on the scalp surface that appeared to become more narrow-band just prior to seizures. High frequency oscillations preceding seizures were present in an average of 35.5% of tripolar concentric ring electrode data channels for all the patients with epilepsy whose seizures were recorded and absent in the corresponding conventional disc electrode data. An average of 78.2% of channels that contained high frequency oscillations were within the seizure onset or irritative zones determined independently by three epileptologists based on conventional disc electrode data and videos.