Thymic regeneration in lethally x-irradiated mice.
Thymic regeneration in lethally x-irradiated mice.
复制标题
致命 X 射线照射小鼠的胸腺再生。
作者：
J. Sharp;D. Thomas
本文研究了750rad的致死剂量X射线全身照射对小鼠淋巴髓系复合体的影响。在暴露后的前4天内，胸腺、脾和淋巴结的重量以及股骨骨髓的细胞量明显减少。随后，观察到胸腺再生阶段，在淋巴髓样复合体的其他部位没有可检测到的再生，在第10天达到最大值。胸腺，从辐射后的第三天到第五天，尽管细胞很少，但仍是一个广泛的氚掺入部位，表明存在进行DNA合成的前体细胞群。脾、淋巴结或骨髓的氚胸腺嘧啶核苷掺入没有观察到类似的变化。在几个品系的小鼠中，胸腺再生在淋巴髓样复合体的其他地方没有检测到再生的情况下，发生在致死范围内的剂量范围内。(身份验证)
The effects of a lethal dose of 750 rad of whole-body x irradiation on the murine lymphomyeloid complex have been investigated. During the first 4 days after exposure there was a marked decrease in the weight of the thymus, spleen, and lymph nodes and in the cellularity of the femoral bone marrow. Subsequently, a phase of thymic regeneration, maximal on the tenth day, was observed in the absence of detectable regeneration elsewhere in the lymphomyeloid complex. The thymus, from the third to the fifth days postirradiation, although very hypocellular, was a site of extensive tritiated thymidine incorporation indicating the presence of a precursor cell population undertaking DNA synthesis. No comparable changes in the tritiated thymidine incorporation of the spleen, lymph nodes or bone marrow were observed. Thymic regeneration in the absence of detectable regeneration elsewhere in the lymphomyeloid complex occurred over a range of doses within the lethal range in several strains of mice. (auth)