SYMPATHETIC CONTROL OF CEREBRAL BLOOD-FLOW IN ACUTE ARTERIAL-HYPERTENSION
SYMPATHETIC CONTROL OF CEREBRAL BLOOD-FLOW IN ACUTE ARTERIAL-HYPERTENSION
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DOI：
10.1111/j.1748-1716.1976.tb10176.x
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发表时间：
1976-01-01
期刊：
影响因子：
--
通讯作者：
LINDER, J
中科院分区：
文献类型：
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作者：
BILL, A;LINDER, J
以10~20赫兹的频率电刺激一侧的[猫]颈交感神经链，由静脉注射引起动脉血压的急剧升高。血管紧张素注射、胸主动脉结扎或主动脉结扎联合间胺类药物注射。用标记的微球测定大脑和小脑的血流量。在高血压时，伊文思蓝渗漏显示大脑中血脑屏障多灶性破坏。击穿仅限于对照侧，或者比刺激侧明显得多。交感神经刺激也能防止血-房水屏障的破坏。在所有实验中，对照侧的大脑血流量均高于刺激侧。血脑屏障被破坏的区域的血流速度大约是正常值的10倍。小脑血流量受高血压影响较小，对交感神经刺激没有明显反应。刺激交感神经到大脑往往可以防止小动脉的强制扩张，从而导致局部血液过度灌流和血脑屏障的破坏。供应大脑的交感神经的作用之一是在交感血管运动活动普遍增加的情况下，通过上部的自动调节来扩大压力区域。
The [cat] cervical sympathetic chain on 1 side was stimulated electrically at 10-20 Hz and an acute rise in arterial blood pressure was produced by: i.v. injection of angiotensin, ligation of the thoracic aorta or ligation of the aorta combined with injection of metaraminol. The blood flow through the cerebrum and the cerebellum was determined by using labeled microspheres. At high blood pressures there was multifocal breakdown of the blood-brain barrier in the cerebrum as indicated by leakage of Evans blue. The breakdown was restricted to the control side or much more marked on that side than on the stimulated side. Sympathetic stimulation also prevented breakdown of the blood-aqueous barrier. The blood flow through the cerebrum on the control side was higher than that on the stimulated side in all experiments. Regions with breakdown of the blood-brain barrier had flow rates which were about 10 times normal values. Cerebellar blood flow was less affected by the hypertension and did not react significantly to sympathetic stimulation. Stimulation of the sympathetic nerves to the brain tends to prevent forced dilatation of the arterioles with a resulting regional overperfusion with blood and breakdown of the blood-brain barrier. One role of the sympathetic nerves supplying the brain is to extend the pressure region with autoregulation in its upper part under conditions of a general increase in sympathetic vasomotor activity.