High serum parathyroid hormone and calcium are risk factors for hypertension in Japanese patients.
High serum parathyroid hormone and calcium are risk factors for hypertension in Japanese patients.
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DOI：
10.1507/endocrj.ej14-0004
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发表时间：
2014
影响因子：
2
通讯作者：
S. Yagi;K. Aihara;Takeshi Kondo;I. Endo;Junko Hotchi;T. Ise;T. Iwase;M. Akaike;Toshio Matsumoto;M. Sata
中科院分区：
文献类型：
--
作者：
S. Yagi;K. Aihara;Takeshi Kondo;I. Endo;Junko Hotchi;T. Ise;T. Iwase;M. Akaike;Toshio Matsumoto;M. Sata
过量的甲状旁腺激素(PTH)被称为原发性甲状旁腺功能亢进症(PHPT)，会导致高钙血症和骨丢失。最近的研究表明，甲状旁腺素与西方国家高血压的发生有关；然而，关于血清甲状旁腺素和钙水平高是日本患者高血压的危险因素，仍存在争议。我们回顾了114例连续来本院就诊的日本患者，这些患者有高钙血症和/或高血压，血钙水平≥为9.8 mg/dL。根据血钙水平分为高钙组(10.2~13.4 mg/dL)和正常血钙组(9.8~10.1 mg/dL)，再分为高甲状旁腺素(50~440 pg/m l)和低甲状旁腺素(8~49 pg/m l)两组。无论是高甲状旁腺素组还是低甲状旁腺素组，高钙血症患者的高血压患病率均高于正常血钙患者。在高钙血症组和正常血钙血症组中，血清甲状旁腺素水平高的患者的高血压患病率均高于血清甲状旁腺素水平低的患者。Logistic多元回归分析显示，血钙(P<；0.05)和甲状旁腺素(P<；0.01)水平是高血压的正相关因素。总而言之，高水平的甲状旁腺素和钙是日本患者高血压的危险因素。
Excess parathyroid hormone (PTH), known as primary hyperparathyroidism (pHPT), results in hypercalcemia and bone loss. Recent studies have shown that PTH is associated with the occurrence of hypertension in Western countries; however, controversy remains regarding high serum levels of PTH and calcium as risk factors for hypertension in Japanese patients. We retrospectively enrolled 114 consecutive Japanese patients who visited our hospital for examination and treatment of hypercalcemia and/or hypertension with serum calcium levels ≥ 9.8 mg/dL. To estimate the prevalence of hypertension, the patients were categorized according to calcium levels into hypercalcemic (10.2-13.4 mg/dL) and normocalcemic (9.8-10.1 mg/dL) groups, which were further categorized into high PTH (50-440 pg/mL) and low PTH (8-49 pg/mL) groups. The prevalence of hypertension was higher in patients with hypercalcemia than in patients with normocalcemia in both the high and low PTH groups. The prevalence of hypertension was higher in patients with high serum PTH levels than in patients with low serum PTH levels in both the hypercalcemic and normocalcemic groups. Logistic multiple regression analysis determined that serum calcium (P < 0.05) and PTH (P < 0.01) levels were positive contributors to hypertension. In conclusion, high serum levels of PTH and calcium are risk factors for hypertension in Japanese patients.