Comparing the effects of estrogen and an herbal medicine on peripheral blood flow in post-menopausal women with hot flashes: Hormone replacement therapy and Gui-Zhi-Fu-Ling-Wan, a Kampo medicine
Comparing the effects of estrogen and an herbal medicine on peripheral blood flow in post-menopausal women with hot flashes: Hormone replacement therapy and Gui-Zhi-Fu-Ling-Wan, a Kampo medicine
复制标题
DOI：
10.1142/s0192415x05002813
复制
发表时间：
2005-01-01
影响因子：
5.7
通讯作者：
Ueki, M
中科院分区：
文献类型：
--
作者：
Ushiroyama, T;Ikeda, A;Ueki, M
我们调查了肢体血流与潮热之间的关系，并比较了激素替代疗法(HRT)和桂枝附子灵丸(凯氏补血灵丸)对绝经后潮热女性的血流变化。352名有更年期症状的绝经后妇女参加了这项研究，年龄在46-58岁之间(平均53.4+/-3.6年)。对131例潮热患者采用激素替代疗法(例)或中药治疗(67例)。用激光多谱勒血流仪测量颌下、中指和第三趾的血流量。绝经后潮热组(12 9例)颌下血流量(13.6±-4.13)显著高于无潮热组(5.48±0.84)(P<；0.0001)。无论哪种疗法，这个部位的血流量都显著减少(p<；0.0001)。另一方面，桂枝附灵丸显著增加(p=0.002)肢体血流量，而激素替代疗法则使其血流量减少，从而证明桂枝附灵丸不影响全身外周血管感觉神经元上血管扩张神经肽的活性。因此，对于更年期症状之一的面部和上身潮热并伴有下身寒冷的患者，建议采用桂枝附灵丸治疗，而不是HRT。
We investigated the association between blood flow in the extremities and hot flashes, and compared change in blood flow following hormone replacement therapy (HRT) and Gui-zhi-fu-ling-wan (Keishi-bukuryo-gan), a herbal therapy in post-menopausal women with hot flashes. Three hundred and fifty-two post-menopausal women aged 46-58 years (mean: 53.4 +/- 3.6 years) with climacteric complaints participated in the study. One hundred and thirty-one patients with hot flashes were treated with HRT (64 cases) or herbal therapy (67 cases). Blood flow was measured with laser doppler fluxmetry under the jaw, in the middle finger and in the third toe. Post-menopausal women with hot flashes (129 cases) showed significantly higher blood flow under the jaw (13.6 +/- 4.13) than women without hot flashes (166 cases) (5.48 +/- 0.84) (p < 0.0001). Blood flow at this site decreased significantly with either therapy (p < 0.0001). On the other hand, the administration of Gui-zhi-fu-ling-wan significantly increased (p = 0.002) the blood flow in the lower extremities, whereas HRT decreased the blood flow.Thus, we have demonstrated that Gui-zhi-fu-ling-wan did not affect the activity of vasodilator neuropeptides on sensory neurons of systemic peripheral vessels uniformly. Therefore, Gui-zhi-fu-ling-wan, rather than HRT, is suggested as an appropriate therapy for treatment of hot flashes in the face and upper body with concomitant coldness in the lower body, which is one of the symptoms of menopause.