Metal ion release from titanium-based prosthetic segmental replacements of long bones in baboons: a long-term study.
Metal ion release from titanium-based prosthetic segmental replacements of long bones in baboons: a long-term study.
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狒狒长骨钛基假体节段替换中金属离子的释放：一项长期研究。
DOI：
10.1002/jor.1100010411
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Urban,RM
中科院分区：
文献类型：
--
作者：
Woodman,JL;Jacobs,JJ;Galante,JO;Urban,RM
45只接受钛基纤维金属复合材料部分骨置换的狒狒与13只没有植入物的对照组一起进行了研究。38只植入植入物的狒狒被处死，并在匀浆的肺、肾、脾、肝、邻近肌肉和区域淋巴结中检测钛、铝和钒的水平。在7只植入了植入物的活狒狒中，采集了血液和尿液样本进行痕量金属分析以及生化和血液学分析。在38只植入植入物的狒狒中，与未植入植入物的6只对照组相比，肺、脾脏、邻近肌肉（股四头肌、比目鱼肌和三头肌）和区域淋巴结（腹股沟、腋窝和腘窝）的钛含量均有所增加。此外，钒在一些动物的肺中显著升高，而铝在邻近肌肉（股四头肌、比目鱼肌和三头肌）、肺和区域淋巴结（腹股沟、腋窝和腘窝）中升高。在7只植入植入物的活狒狒中，与未植入植入物的7只活对照相比，尿钛水平增加了6倍（p < 0.0005）。此外，植入组血清中铝含量升高（p < 0.0005）。生化和血液学研究没有显示，在血清电解质、肝肾功能测试或全血细胞计数方面，7只植入植入物的活狒狒与对照组之间存在统计学上的显著差异。
Forty‐five baboons that had received titanium‐based fiber metal composite segmental bone replacements were studied along with 13 controls without implants. Thirty‐eight baboons with implants were sacrificed, and titanium, aluminum, and vanadium levels were assayed in homogenized lung, kidney, spleen, liver, adjacent muscle, and regional lymph nodes. In seven living baboons with implants, blood and urine samples were obtained for trace metal analysis as well as for biochemical and hematological profiles. In the 38 sacrificed baboons with implants, increased titanium levels were noted in the lungs, spleen, adjacent muscle (quadriceps, soleus, and triceps), and regional lymph nodes (inguinal, axillary, and popliteal) in comparison to those of six sacrificed controls without implants. In addition, vanadium was significantly elevated in the lungs of some animals, while aluminum increases were noted in adjacent muscle (quadriceps, soleus, and triceps), lung, and regional lymph nodes (inguinal, axillary, and popliteal). In the seven living baboons with implants, a sixfold increase (p < 0.0005) in the urine titanium level was noted in comparison to that of seven living controls without implants. Additionally, elevated aluminum levels were found in the serum (p < 0.0005) of the group with implants. Biochemical and hematological studies did not indicate statistically significant differences in serum electrolytes, in liver and renal function tests, or in complete blood counts between the seven living baboons with implants and their controls.