Intestinal Microbiota Distinguish Gout Patients from Healthy Humans.
Intestinal Microbiota Distinguish Gout Patients from Healthy Humans.
复制标题
DOI：
10.1038/srep20602
复制
发表时间：
2016-02-08
影响因子：
4.6
通讯作者：
Zhang H
中科院分区：
文献类型：
--
作者：
Guo Z;Zhang J;Wang Z;Ang KY;Huang S;Hou Q;Su X;Qiao J;Zheng Y;Wang L;Koh E;Danliang H;Xu J;Lee YK;Zhang H
目前基于血液的方法诊断痛风可能是低灵敏度和滞后。在这里，通过一项68名成员的队列研究，包括33名健康个体和35名患病个体，我们报告了痛风患者的肠道微生物群在有机体和功能结构上都与健康个体高度不同。在痛风中，卡苗拟杆菌和溶木拟杆菌被富集，而prausnitzii Faecalibacterium和pseudoatenulatum双歧杆菌被耗尽。建立的痛风参考微生物基因目录显示痛风患者嘌呤降解和丁酸生物合成紊乱。在另外一个15人验证组中，通过17种痛风相关细菌的诊断模型准确率达到88.9%，高于基于血尿酸的方法。痛风的肠道微生物群更类似于2型糖尿病，而不是肝硬化，而在每种代谢综合征中，prausnitzii粪杆菌的消耗和丁酸盐生物合成的减少是共同的。因此，痛风微生物指数作为一种新的、灵敏的、无创的、通过粪便微生物群诊断痛风的方法被提出。
Current blood-based approach for gout diagnosis can be of low sensitivity and hysteretic. Here via a 68-member cohort of 33 healthy and 35 diseased individuals, we reported that the intestinal microbiota of gout patients are highly distinct from healthy individuals in both organismal and functional structures. In gout, Bacteroides caccae and Bacteroides xylanisolvens are enriched yet Faecalibacterium prausnitzii and Bifidobacterium pseudocatenulatum depleted. The established reference microbial gene catalogue for gout revealed disorder in purine degradation and butyric acid biosynthesis in gout patients. In an additional 15-member validation-group, a diagnosis model via 17 gout-associated bacteria reached 88.9% accuracy, higher than the blood-uric-acid based approach. Intestinal microbiota of gout are more similar to those of type-2 diabetes than to liver cirrhosis, whereas depletion of Faecalibacterium prausnitzii and reduced butyrate biosynthesis are shared in each of the metabolic syndromes. Thus the Microbial Index of Gout was proposed as a novel, sensitive and non-invasive strategy for diagnosing gout via fecal microbiota.